{"id":"W2103080419","doi":"10.1371/journal.ppat.1002738","title":"Structures of Merkel Cell Polyomavirus VP1 Complexes Define a Sialic Acid Binding Site Required for Infection","year":2012,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Polyomavirus and related diseases","field":"Medicine","cited_by":93,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada; Institute for Biological Sciences","funders":"National Cancer Institute; Japan Society for the Promotion of Science; National Institutes of Health; Ministry of Education, Culture, Sports, Science and Technology; Deutsche Forschungsgemeinschaft","keywords":"Merkel cell polyomavirus; Sialic acid; Glycan; Merkel cell carcinoma; Biology; Virology; Receptor; N-Acetylneuraminic acid; Viral entry; Polyomavirus Infections; Glycoprotein; Cell biology; Virus; Viral replication; Molecular biology; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007081321,0.0004373588,0.0002935606,0.0001583456,0.0002369464,0.0004688735,0.000313655,0.0003137232,0.001065937],"category_scores_gemma":[0.0001947552,0.0002340894,0.0003333023,0.000176075,0.0001890013,0.0003657502,0.0003246305,0.000592421,0.0003932802],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000720711,"about_ca_system_score_gemma":0.0002021871,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002201886,"about_ca_topic_score_gemma":0.002130415,"domain_scores_codex":[0.9999219,0.0000101989,0.000004362312,0.0000192299,0.00002084136,0.00002334705],"domain_scores_gemma":[0.9999181,0.00001216437,0.00003076225,0.00000695811,0.00001154938,0.00002044833],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002561914,0.00003368014,0.002259027,0.00009150541,0.00002861435,0.0002578218,0.0001487796,0.0009211068,0.9936885,0.0005197575,0.0001018664,0.001693076],"study_design_scores_gemma":[0.00006103003,0.0005003405,0.09281135,0.00005575384,0.0001117119,0.001570974,0.0005370512,0.01167582,0.8839331,0.001140143,0.007547892,0.00005491071],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967533,0.0009893032,0.00123389,0.00002969185,0.000007771412,0.00001029877,0.0001136917,0.00002285705,0.0008391825],"genre_scores_gemma":[0.9962252,0.0004112506,0.001710463,0.00004751489,0.000004276364,0.000009618691,0.0005606628,0.00001407482,0.001016957],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002201886,"threshold_uncertainty_score":0.005229115,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04249017020015791,"score_gpt":0.2871934519953896,"score_spread":0.2447032817952317,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}