{"id":"W2103080419","doi":"10.1371/journal.ppat.1002738","title":"Structures of Merkel Cell Polyomavirus VP1 Complexes Define a Sialic Acid Binding Site Required for Infection","year":2012,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Polyomavirus and related diseases","field":"Medicine","cited_by":93,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada; Institute for Biological Sciences","funders":"National Cancer Institute; Japan Society for the Promotion of Science; National Institutes of Health; Ministry of Education, Culture, Sports, Science and Technology; Deutsche Forschungsgemeinschaft","keywords":"Merkel cell polyomavirus; Sialic acid; Glycan; Merkel cell carcinoma; Biology; Virology; Receptor; N-Acetylneuraminic acid; Viral entry; Polyomavirus Infections; Glycoprotein; Cell biology; Virus; Viral replication; Molecular biology; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001131679,0.00021391,0.0004273194,0.0002177753,0.0001411585,0.00001109632,0.00005667334,0.0001767388,0.0001266151],"category_scores_gemma":[0.0001734437,0.0001790258,0.0002628308,0.0002304903,0.00008398507,0.0001229607,0.00004081811,0.0001180474,0.00004903882],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005385421,"about_ca_system_score_gemma":0.00007124069,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008516412,"about_ca_topic_score_gemma":0.00000780784,"domain_scores_codex":[0.9986485,0.00004697091,0.0003711639,0.0002194459,0.0002461298,0.0004677619],"domain_scores_gemma":[0.998987,0.00007415978,0.0002143569,0.0002843509,0.00008866449,0.0003515226],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002877651,0.0005046402,0.05846234,0.0003157325,0.0001563434,0.000005717056,0.0003244661,0.000003462712,0.9384439,0.0002018198,0.0003580106,0.000935827],"study_design_scores_gemma":[0.002822873,0.0005124158,0.1055188,0.0001776849,0.001719037,0.00004676687,0.00006641023,0.0002030467,0.886287,0.0001693599,0.002138104,0.0003385228],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932405,0.004047081,0.000139845,0.00005096889,0.0002695879,0.0005924139,0.000873567,0.0001050297,0.0006809814],"genre_scores_gemma":[0.9974016,0.0001830326,0.001361195,0.0001286976,0.0003793786,0.00004241435,0.0002987274,0.0000509018,0.0001540368],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05215691,"threshold_uncertainty_score":0.7300459,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04249017020015791,"score_gpt":0.2871934519953896,"score_spread":0.2447032817952317,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}