{"id":"W2103089222","doi":"10.1086/498651","title":"Replication of Putative Candidate-Gene Associations with Rheumatoid Arthritis in >4,000 Samples from North America and Sweden: Association of Susceptibility with PTPN22, CTLA4, and PADI4","year":2005,"lang":"en","type":"article","venue":"The American Journal of Human Genetics","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":561,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Montreal Heart Institute","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institutes of Health; Broad Institute; National Institute of Allergy and Infectious Diseases; Abbott Laboratories","keywords":"PTPN22; Replication (statistics); Rheumatoid arthritis; Candidate gene; Genetics; Gene; Biology; Association (psychology); Computational biology; Evolutionary biology; Medicine; Genotype; Single-nucleotide polymorphism; Immunology; Virology; Psychology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002842584,0.001066441,0.001172435,0.001376473,0.001752304,0.001455991,0.001057749,0.001000175,0.002667946],"category_scores_gemma":[0.006374027,0.0008116168,0.001511985,0.002051487,0.0008372236,0.0003272353,0.001056325,0.001102244,0.0006943124],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005272987,"about_ca_system_score_gemma":0.0009021217,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.03779491,"about_ca_topic_score_gemma":0.0320824,"domain_scores_codex":[0.9964709,0.001681466,0.0002461263,0.0009057412,0.0003574306,0.0003382956],"domain_scores_gemma":[0.9956117,0.001590856,0.0005887296,0.001070971,0.0006407776,0.000496969],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001418837,0.00009220071,0.9835997,0.00003552506,0.001405954,0.0005310447,0.0007282632,0.0002492101,0.008704263,0.00007384179,0.0007247661,0.002436538],"study_design_scores_gemma":[0.0001446057,0.0001399074,0.9969342,0.000009707776,0.0004592546,0.0004599708,0.0003149437,0.0002000909,0.000615963,0.00003352434,0.0006804139,0.000007479508],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979717,0.0001671471,0.0003250779,0.00006232461,0.00002119831,0.00001346669,0.001047869,0.00001291486,0.0003782169],"genre_scores_gemma":[0.9963774,0.00009241887,0.0003475142,0.00008624439,0.00002091484,0.00004727723,0.00217002,0.00002298687,0.0008351925],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03779491,"threshold_uncertainty_score":0.07514983,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01484659420790665,"score_gpt":0.2717562664032445,"score_spread":0.2569096721953378,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}