{"id":"W2103089222","doi":"10.1086/498651","title":"Replication of Putative Candidate-Gene Associations with Rheumatoid Arthritis in >4,000 Samples from North America and Sweden: Association of Susceptibility with PTPN22, CTLA4, and PADI4","year":2005,"lang":"en","type":"article","venue":"The American Journal of Human Genetics","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":561,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Montreal Heart Institute","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institutes of Health; Broad Institute; National Institute of Allergy and Infectious Diseases; Abbott Laboratories","keywords":"PTPN22; Replication (statistics); Rheumatoid arthritis; Candidate gene; Genetics; Gene; Biology; Association (psychology); Computational biology; Evolutionary biology; Medicine; Genotype; Single-nucleotide polymorphism; Immunology; Virology; Psychology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003089058,0.0001123896,0.000510072,0.0001148942,0.00007602634,0.00001501187,0.00007294807,0.00002248127,0.00001468972],"category_scores_gemma":[0.0001407519,0.00007651876,0.00004222342,0.000247617,0.0003106221,0.00006589374,0.00001894375,0.0002107544,1.897718e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001316421,"about_ca_system_score_gemma":0.0001149491,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001083248,"about_ca_topic_score_gemma":0.003013035,"domain_scores_codex":[0.9986987,0.0001413538,0.000581369,0.0001603774,0.0002959737,0.0001222998],"domain_scores_gemma":[0.997219,0.0002846248,0.00173944,0.0002471324,0.0004404138,0.00006938328],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003809021,0.0002302611,0.8652928,0.000007911605,0.0003060569,0.000002519917,0.006654197,0.0006861242,0.1044384,0.000007617966,0.00004374367,0.02194946],"study_design_scores_gemma":[0.001241032,0.002689332,0.9689732,0.0001140891,0.0001183014,0.0000420161,0.002079919,0.0001358507,0.02432226,0.00006666438,0.0001290878,0.00008822073],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998049,0.0004915153,0.0004028702,0.0006191985,0.0000082806,0.0001555621,0.0002439556,0.000004141616,0.00002549541],"genre_scores_gemma":[0.9946427,0.001393824,0.003757421,0.000070116,0.00005468073,0.000003293461,0.00005746887,0.00001352308,0.000006976581],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1036805,"threshold_uncertainty_score":0.3120344,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01484659420790665,"score_gpt":0.2717562664032445,"score_spread":0.2569096721953378,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}