{"id":"W2103100938","doi":"10.1038/mtna.2014.41","title":"Agonistic CD200R1 DNA Aptamers Are Potent Immunosuppressants That Prolong Allogeneic Skin Graft Survival","year":2014,"lang":"en","type":"article","venue":"Molecular Therapy — Nucleic Acids","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; University of Toronto; Sunnybrook Health Science Centre","funders":"","keywords":"Aptamer; Immunogenicity; Immune system; Immunology; Inflammation; Cancer research; Biology; Cell biology; Molecular biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004026098,0.0004903334,0.0004173566,0.0002003078,0.0004554065,0.0002688085,0.0007910116,0.0001636554,0.0001872352],"category_scores_gemma":[0.0002332084,0.0004594048,0.0002663738,0.000359386,0.0001888465,0.0002114088,0.0001345869,0.0003318457,0.0003376518],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000415652,"about_ca_system_score_gemma":0.00004038107,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005066808,"about_ca_topic_score_gemma":0.000003244058,"domain_scores_codex":[0.9959503,0.001005211,0.0004557627,0.0009954761,0.0009354295,0.0006577829],"domain_scores_gemma":[0.99825,0.0001139076,0.0003184553,0.001019681,0.00006999587,0.0002279696],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001094713,0.0001209223,0.0001774286,0.00001092753,0.00001519475,0.00009244093,0.0001191141,0.0005491931,0.9907348,0.002310305,0.00008141612,0.005678752],"study_design_scores_gemma":[0.001515227,0.0002489823,0.003364621,0.00001584428,0.00001732305,0.00005888238,0.00003615468,0.003631192,0.982228,0.000763356,0.007629272,0.000491104],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9787002,0.00006799853,0.01625443,0.001136079,0.001146375,0.0007494257,0.00001950294,0.0005451429,0.001380879],"genre_scores_gemma":[0.9936545,0.000189209,0.000302566,0.005086204,0.0001078875,0.00007316717,0.00001374811,0.0001738614,0.0003988434],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01595187,"threshold_uncertainty_score":0.9997858,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02988824590077677,"score_gpt":0.2416973354389921,"score_spread":0.2118090895382153,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}