{"id":"W2103107517","doi":"10.1039/b912993f","title":"A miniaturized screen for inhibitors of Jumonji histonedemethylases","year":2009,"lang":"en","type":"article","venue":"Molecular BioSystems","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":93,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Biotechnology and Biological Sciences Research Council; Canadian Institutes of Health Research; National Institutes of Health; Wellcome Trust","keywords":"High-throughput screening; Demethylation; Biochemistry; Computational biology; Enzyme; Chemistry; Combinatorial chemistry; Biology; Gene; DNA methylation; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007935226,0.001261775,0.001453866,0.0009100036,0.0003068966,0.0006341352,0.001024575,0.0006750108,0.00165616],"category_scores_gemma":[0.0005947559,0.000527363,0.0004631754,0.0004789499,0.0003357009,0.0002816796,0.0005367763,0.00103313,0.0008651876],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005098702,"about_ca_system_score_gemma":0.0006329553,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005969054,"about_ca_topic_score_gemma":0.002191343,"domain_scores_codex":[0.9992248,0.0001268167,0.00005543085,0.0001380278,0.0003725988,0.00008234147],"domain_scores_gemma":[0.9996837,0.00009616173,0.00004755858,0.00005356894,0.0000586075,0.00006032587],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000648937,0.0001013362,0.000112221,0.00004998454,0.00001962471,0.00003433255,0.00001080552,0.0002057748,0.9944673,0.00004823829,0.0001489814,0.004736581],"study_design_scores_gemma":[0.0000849517,0.001112494,0.001701687,0.000006538994,0.00006517934,0.0002331241,0.00001025382,0.00142913,0.9914213,0.00002570671,0.003894123,0.00001559414],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8175638,0.005629655,0.1572665,0.0007680167,0.000254096,0.002862901,0.006148806,0.002890053,0.006616222],"genre_scores_gemma":[0.7534577,0.005515906,0.208596,0.000465105,0.000120852,0.002663343,0.01255277,0.000266879,0.01636135],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00165616,"threshold_uncertainty_score":0.005540431,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008677130551507919,"score_gpt":0.261774529026684,"score_spread":0.2530973984751761,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}