{"id":"W2103107517","doi":"10.1039/b912993f","title":"A miniaturized screen for inhibitors of Jumonji histonedemethylases","year":2009,"lang":"en","type":"article","venue":"Molecular BioSystems","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":93,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Biotechnology and Biological Sciences Research Council; Canadian Institutes of Health Research; National Institutes of Health; Wellcome Trust","keywords":"High-throughput screening; Demethylation; Biochemistry; Computational biology; Enzyme; Chemistry; Combinatorial chemistry; Biology; Gene; DNA methylation; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002981837,0.0001742515,0.0002476384,0.00008382005,0.00004742905,0.0000149785,0.0001628932,0.0001979261,0.000002828198],"category_scores_gemma":[0.0001533781,0.0001691139,0.0002271269,0.0001163966,0.00003924004,0.000002303365,0.00002794069,0.00003920391,0.000001817688],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001321307,"about_ca_system_score_gemma":0.00005106098,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001854915,"about_ca_topic_score_gemma":0.000006547431,"domain_scores_codex":[0.9988018,0.0000754353,0.0003882655,0.0003359907,0.0001781775,0.0002203686],"domain_scores_gemma":[0.9991458,0.00001515227,0.0002034203,0.0003818902,0.0001724487,0.0000813113],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008728296,0.00006124742,0.0001363666,0.00003396676,0.0000374509,0.000001498237,0.00001883765,0.00002246085,0.9967818,0.0001704561,0.0008330807,0.0018155],"study_design_scores_gemma":[0.0007475297,0.0008088751,0.0002833295,0.00003031069,0.00003171764,0.000001521955,0.00001641309,0.00004815366,0.9687195,0.0001869059,0.02893215,0.0001935444],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9791936,0.007490603,0.01137198,0.0001714857,0.0002187862,0.000614196,0.00006269904,0.00001592921,0.0008607177],"genre_scores_gemma":[0.9943889,0.00006801572,0.004740856,0.00009711702,0.0002135565,0.00002301502,0.0002006279,0.00002389251,0.00024402],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02809907,"threshold_uncertainty_score":0.6896267,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008677130551507919,"score_gpt":0.261774529026684,"score_spread":0.2530973984751761,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}