{"id":"W2103112313","doi":"10.1128/aac.01090-12","title":"5S Clavam Biosynthesis Is Controlled by an Atypical Two-Component Regulatory System in Streptomyces clavuligerus","year":2012,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Directorate for Biological Sciences","keywords":"Streptomyces clavuligerus; Dephosphorylation; Mutant; Gene cluster; Gene; Transcription (linguistics); Phosphorylation; Chemistry; Streptomyces; Biochemistry; Molecular biology; Biology; Genetics; Phosphatase; Actinomycetales; Bacteria","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00010864,0.0005155602,0.0003177229,0.0003781026,0.0001690674,0.0004224247,0.0001730922,0.0001928217,0.0003946919],"category_scores_gemma":[0.0001858875,0.0001922106,0.0002785858,0.0002308837,0.000215293,0.0001128929,0.0003044228,0.0002428889,0.0004332983],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005746547,"about_ca_system_score_gemma":0.0002826338,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001676127,"about_ca_topic_score_gemma":0.001599863,"domain_scores_codex":[0.9997539,0.00004634505,0.00002583654,0.0000686537,0.00006789548,0.00003727977],"domain_scores_gemma":[0.9998065,0.00003043493,0.00006847298,0.00002682822,0.00002119671,0.00004653186],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000790855,0.00001448871,0.0005390716,0.00001513363,0.000002277598,0.00005334724,0.000009443156,0.0001287091,0.9981828,0.00005728632,0.00001187915,0.0009066213],"study_design_scores_gemma":[0.0000504689,0.000366772,0.03516579,0.00001459221,0.00003581789,0.0008800615,0.0001089388,0.006298748,0.954117,0.0001895187,0.002739204,0.00003308531],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964323,0.0003574757,0.002085564,0.00003582639,0.000008218778,0.00001220679,0.0002033757,0.0001553495,0.0007095794],"genre_scores_gemma":[0.9957942,0.0001283641,0.002174007,0.00002111928,0.000004255961,0.00001425735,0.0008757879,0.000028089,0.0009598589],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001676127,"threshold_uncertainty_score":0.004169405,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01170405821381911,"score_gpt":0.2600852717856675,"score_spread":0.2483812135718484,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}