{"id":"W2103114638","doi":"10.1158/1078-0432.ccr-14-2993","title":"PTEN Loss Is Associated with Worse Outcome in <i>HER2</i> -Amplified Breast Cancer Patients but Is Not Associated with Trastuzumab Resistance","year":2015,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta Hospital; University of Alberta","funders":"National Cancer Institute","keywords":"PTEN; Trastuzumab; Breast cancer; Medicine; Immunohistochemistry; Population; Cancer; Oncology; Internal medicine; Cancer research; Pathology; Biology; PI3K/AKT/mTOR pathway; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007279086,0.0002386825,0.0004645045,0.0004313352,0.0002041371,0.0004229806,0.0002310161,0.0003842139,0.001217936],"category_scores_gemma":[0.001402788,0.0001328368,0.000288454,0.0003868424,0.0003950237,0.0002302879,0.0002407245,0.0004988185,0.0001475728],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001972668,"about_ca_system_score_gemma":0.0002324425,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003632078,"about_ca_topic_score_gemma":0.0004451936,"domain_scores_codex":[0.9997011,0.00007460456,0.00003277094,0.00007786331,0.00006044688,0.00005316926],"domain_scores_gemma":[0.9987043,0.0002643232,0.0006711287,0.00006452116,0.00005089715,0.000244717],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.006343775,0.0002592699,0.9751383,0.00003748165,0.000134893,0.0004322676,0.00003527296,0.0001462073,0.01149977,0.0000318062,0.0001476111,0.005793313],"study_design_scores_gemma":[0.0002083439,0.001778741,0.9940182,0.00000705912,0.0001436035,0.001536491,0.00003805825,0.0003261803,0.001546925,0.00006614506,0.0003239198,0.000006242677],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994109,0.0001836627,0.00005197895,0.00003433961,0.000003070684,0.000007251723,0.00004725025,0.000003029355,0.0002584752],"genre_scores_gemma":[0.9996811,0.00005275791,0.00003879536,0.00003172996,0.00001105172,0.000006175355,0.0001133077,0.000001311517,0.00006379679],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001217936,"threshold_uncertainty_score":0.004074395,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.332316024989978,"score_gpt":0.5229535913488315,"score_spread":0.1906375663588535,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}