{"id":"W2103125265","doi":"10.1152/ajprenal.00516.2014","title":"Glycogen synthase kinase 3α regulates urine concentrating mechanism in mice","year":2015,"lang":"en","type":"article","venue":"American Journal of Physiology-Renal Physiology","topic":"Ion Transport and Channel Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; U.S. Public Health Service; Lundbeckfonden; Vanderbilt University Medical Center","keywords":"Polyuria; Internal medicine; Endocrinology; Aquaporin 2; Vasopressin; Urine osmolality; GSK-3; Chemistry; GSK3B; Urine; Aquaporin 3; Nephrogenic diabetes insipidus; Knockout mouse; Biology; Kinase; Aquaporin; Medicine; Biochemistry; Diabetes mellitus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003094348,0.0002597733,0.0005717516,0.0001240078,0.00004796409,0.000006877589,0.0003147737,0.0001380782,0.00002513605],"category_scores_gemma":[0.000082906,0.0002234915,0.0001919073,0.0002149925,0.0004280156,0.00001813414,0.00006277658,0.000242847,0.000007816207],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000444051,"about_ca_system_score_gemma":0.000202,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006338553,"about_ca_topic_score_gemma":0.00002008044,"domain_scores_codex":[0.9981933,0.0002578642,0.000614312,0.0003546421,0.0001563882,0.0004235265],"domain_scores_gemma":[0.9985754,0.00003762299,0.0006728007,0.0002237901,0.0002842046,0.0002061284],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001353917,0.0001439309,0.0001423575,0.00001023913,0.00009334395,0.00001641875,0.0001453856,0.002223691,0.9943317,0.0002010397,0.0002243971,0.001113595],"study_design_scores_gemma":[0.002542826,0.004072256,0.01807386,0.00006658394,0.00005658892,0.0001512186,0.00100599,0.0003484905,0.9670231,0.005196723,0.001044063,0.0004182993],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987339,0.0003442013,0.0002414739,0.0001879803,0.0003166199,0.0001037276,0.00001157049,0.000008148141,0.00005231204],"genre_scores_gemma":[0.9978181,0.00009099363,0.0007734786,0.0003321577,0.0008094085,0.000006769672,0.0001049423,0.00002676349,0.00003742757],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02730859,"threshold_uncertainty_score":0.911372,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008930812090477757,"score_gpt":0.2355061141916331,"score_spread":0.2265753021011553,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}