{"id":"W2103125424","doi":"10.1021/jo030192r","title":"Derivatized Amino Acids Relevant to Native Peptide Synthesis by Chemical Ligation and Acyl Transfer","year":2003,"lang":"en","type":"article","venue":"The Journal of Organic Chemistry","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Native chemical ligation; Glycine; Alkylation; Amino acid; Alanine; Serine; Chemistry; Peptide; Chemical ligation; Amide; Acylation; Stereochemistry; Peptide synthesis; Combinatorial chemistry; Chemical synthesis; Organic chemistry; Biochemistry; Catalysis; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002094307,0.000442322,0.0003246543,0.0002027345,0.0001951359,0.0002634188,0.0002766087,0.0002932285,0.002408113],"category_scores_gemma":[0.0002871198,0.000274919,0.0002406665,0.0002570699,0.0002322247,0.0002913984,0.0001717937,0.0007110595,0.001278445],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002743885,"about_ca_system_score_gemma":0.0003515559,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000272866,"about_ca_topic_score_gemma":0.0004708625,"domain_scores_codex":[0.999863,0.00002482943,0.00001538192,0.00002995835,0.00003803566,0.00002871408],"domain_scores_gemma":[0.9998178,0.00004339794,0.00003633483,0.00004063592,0.00003000706,0.00003177855],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005230403,0.000008110859,0.00002302186,0.00003637424,0.00000154784,0.00004154184,0.000009247674,0.00006090168,0.9987034,0.0001568339,0.00001201838,0.0008947022],"study_design_scores_gemma":[0.000008083619,0.00009240683,0.0002778966,0.00000286767,0.000007065451,0.0001426893,0.000004880709,0.00009590773,0.9959844,0.00009794868,0.003282485,0.000003367819],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9100493,0.002800117,0.07789685,0.0001412669,0.0001921975,0.0003791293,0.001729038,0.0004826397,0.006329319],"genre_scores_gemma":[0.8824998,0.003467139,0.09826089,0.0001383503,0.00006264618,0.0002862756,0.004919177,0.0002433155,0.01012248],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002408113,"threshold_uncertainty_score":0.008055925,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004545375114147592,"score_gpt":0.2042473355458098,"score_spread":0.1997019604316622,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}