{"id":"W2103127692","doi":"10.1091/mbc.e07-01-0053","title":"A Novel Function of eIF2α Kinases as Inducers of the Phosphoinositide-3 Kinase Signaling Pathway","year":2007,"lang":"en","type":"article","venue":"Molecular Biology of the Cell","topic":"RNA regulation and disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":84,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"York University; Medical School, University of Michigan; National Cancer Institute; School of Medicine, New York University; Terry Fox Foundation; Canadian Institutes of Health Research; Ohio State University","keywords":"Biology; PI3K/AKT/mTOR pathway; Cell biology; Eukaryotic initiation factor; Signal transduction; Phosphorylation; eIF2; EIF-2 kinase; Kinase; Protein kinase B; Phosphoinositide 3-kinase; Translation (biology); Protein kinase A; Biochemistry; Cyclin-dependent kinase 2; Messenger RNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001972283,0.0006502567,0.0002297419,0.0002409112,0.0001937864,0.0004686709,0.0002239634,0.0002787952,0.0007121406],"category_scores_gemma":[0.00008964702,0.0001216976,0.0002333985,0.000128518,0.0002552555,0.0003169451,0.0002286542,0.0004122633,0.0003927297],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002943077,"about_ca_system_score_gemma":0.0001945282,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006637201,"about_ca_topic_score_gemma":0.0001221726,"domain_scores_codex":[0.9999089,0.00001328692,0.000007595215,0.00002990759,0.00002110645,0.00001919737],"domain_scores_gemma":[0.9999462,0.00000634854,0.00001246908,0.00001245614,0.000008013376,0.00001447772],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002018253,0.00003272574,0.0002551838,0.00006825509,0.000005323085,0.000244495,0.000008024997,0.0001277755,0.991795,0.001867367,0.0001371002,0.005256952],"study_design_scores_gemma":[0.00005748881,0.0003083225,0.005117444,0.0000134278,0.00002824722,0.001266693,0.00001816494,0.001379025,0.9738433,0.0009468314,0.01701227,0.000008917105],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.898344,0.03743331,0.04590376,0.0009799385,0.0006537529,0.0001263179,0.0007608649,0.0008509304,0.014947],"genre_scores_gemma":[0.9752518,0.007323001,0.01114004,0.0001525852,0.0001618634,0.00005195373,0.0005503074,0.00003236851,0.005336166],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007121406,"threshold_uncertainty_score":0.002382278,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00718598949130824,"score_gpt":0.227639178658225,"score_spread":0.2204531891669168,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}