{"id":"W2103128020","doi":"10.1016/j.ymeth.2007.01.007","title":"Detergents for the stabilization and crystallization of membrane proteins","year":2007,"lang":"en","type":"review","venue":"Methods","topic":"Lipid Membrane Structure and Behavior","field":"Biochemistry, Genetics and Molecular Biology","cited_by":524,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ontario Institute for Cancer Research; University of Toronto","funders":"","keywords":"Solubilization; Membrane protein; Chemistry; Reagent; Membrane; Lipid bilayer; Chromatography; Crystallization; Protein aggregation; Biochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002798758,0.002974034,0.002915628,0.00366153,0.000706816,0.001204923,0.003762603,0.001831803,0.00214704],"category_scores_gemma":[0.001586404,0.00120513,0.000843524,0.00418645,0.001969832,0.002363136,0.001577975,0.004371652,0.005215881],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001535074,"about_ca_system_score_gemma":0.001267123,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001431985,"about_ca_topic_score_gemma":0.001994818,"domain_scores_codex":[0.9990504,0.0001426567,0.0001254072,0.0001675286,0.0004419364,0.00007204177],"domain_scores_gemma":[0.9992492,0.0003052609,0.0001115727,0.0000696983,0.0002105542,0.00005363386],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001523332,0.0002769823,0.0001590337,0.01299151,0.0001547449,0.0002592375,0.00008062126,0.001063775,0.0409494,0.01203156,0.0332038,0.8986769],"study_design_scores_gemma":[0.00008009517,0.0001105108,0.0004146351,0.001162156,0.0001155677,0.001332377,0.00003907952,0.0004991542,0.04261817,0.004749358,0.9488201,0.00005865681],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004484809,0.9869791,0.009746588,0.0003531215,0.0007694187,0.00004092566,0.00007442239,0.00007746229,0.001510388],"genre_scores_gemma":[0.001330493,0.987455,0.00775023,0.0002863195,0.0003299345,0.00008767976,0.0002902922,0.00002440081,0.002445605],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003762603,"threshold_uncertainty_score":0.01480138,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08916372637672516,"score_gpt":0.4441242834291527,"score_spread":0.3549605570524276,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}