{"id":"W2103155016","doi":"10.1016/j.clcc.2013.11.002","title":"Correlation of Lactate Dehydrogenase Isoenzyme Profile With Outcome in Patients With Advanced Colorectal Cancer Treated With Chemotherapy and Bevacizumab or Cediranib: Retrospective Analysis of the HORIZON I Study","year":2013,"lang":"en","type":"article","venue":"Clinical Colorectal Cancer","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa","funders":"","keywords":"Bevacizumab; Medicine; Lactate dehydrogenase; Internal medicine; Colorectal cancer; Chemotherapy; Isozyme; Gastroenterology; Oncology; Cancer; Enzyme; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000163214,0.0002655457,0.0007570525,0.00008738787,0.00005617742,0.00001186449,0.0001555873,0.0001489107,0.0000750723],"category_scores_gemma":[0.00006774003,0.0001443579,0.000112793,0.0008637744,0.0003403741,0.00002262848,0.00005123761,0.0002024275,2.862639e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008113254,"about_ca_system_score_gemma":0.0002372137,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001132553,"about_ca_topic_score_gemma":0.01609096,"domain_scores_codex":[0.9981738,0.0001428896,0.0005645619,0.0005638979,0.0003023102,0.0002525102],"domain_scores_gemma":[0.9986152,0.00004624017,0.0005321311,0.0002636148,0.0004494026,0.0000933811],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01518493,0.0005952364,0.9747366,0.00001576225,0.001090451,5.41462e-7,0.0001968286,0.0004508972,0.004583948,0.000001060962,0.00002752982,0.003116257],"study_design_scores_gemma":[0.00880271,0.009148756,0.9672419,0.00003892042,0.0007231451,5.386842e-7,0.000159147,0.0002682015,0.01334737,0.000001121496,0.00004094757,0.0002272379],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973668,0.0002913846,0.00001217221,0.00002987942,0.0001397791,0.001929485,0.0001844254,0.000009252378,0.0000368586],"genre_scores_gemma":[0.9989338,0.0002452768,0.00007200606,0.00004887335,0.00008024411,0.0004491862,0.00004442614,0.00003643413,0.00008978462],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01495841,"threshold_uncertainty_score":0.8979136,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01024558012326759,"score_gpt":0.2934762160219493,"score_spread":0.2832306358986817,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}