{"id":"W2103155016","doi":"10.1016/j.clcc.2013.11.002","title":"Correlation of Lactate Dehydrogenase Isoenzyme Profile With Outcome in Patients With Advanced Colorectal Cancer Treated With Chemotherapy and Bevacizumab or Cediranib: Retrospective Analysis of the HORIZON I Study","year":2013,"lang":"en","type":"article","venue":"Clinical Colorectal Cancer","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa","funders":"","keywords":"Bevacizumab; Medicine; Lactate dehydrogenase; Internal medicine; Colorectal cancer; Chemotherapy; Isozyme; Gastroenterology; Oncology; Cancer; Enzyme; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004252898,0.0002049082,0.0004831704,0.0005803715,0.0002315815,0.0005315978,0.0002317646,0.0003170251,0.0006035],"category_scores_gemma":[0.00125574,0.0002292524,0.0004217196,0.0009829444,0.0002755225,0.0003704699,0.0003274922,0.0003778902,0.0001013751],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004896265,"about_ca_system_score_gemma":0.0003818512,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003916187,"about_ca_topic_score_gemma":0.003178097,"domain_scores_codex":[0.9996663,0.00007681991,0.0000406195,0.00008126127,0.00006056289,0.00007447189],"domain_scores_gemma":[0.9987092,0.0001885933,0.0006925515,0.00006704248,0.00009806007,0.0002445511],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007544336,0.00002233613,0.9981212,0.000004726618,0.00007181151,0.00005755515,0.00001502595,0.00003813731,0.0002867676,0.000009159914,0.00003310509,0.0005858606],"study_design_scores_gemma":[0.00002142042,0.0001986376,0.9991664,0.000001894488,0.00006503372,0.000200954,0.00004990828,0.0001261448,0.00006748328,0.00001118529,0.00008761582,0.000003423912],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992377,0.0003145762,0.00004321554,0.0000160409,0.00000292902,0.000003066509,0.0002223104,0.000001301322,0.0001588743],"genre_scores_gemma":[0.9995105,0.00009118368,0.00002649904,0.000009626595,0.000006365662,0.000002616773,0.0003146975,9.625268e-7,0.00003749193],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003916187,"threshold_uncertainty_score":0.007786751,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01024558012326759,"score_gpt":0.2934762160219493,"score_spread":0.2832306358986817,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}