{"id":"W2103172754","doi":"10.1136/jmedgenet-2015-103094","title":"Hereditary diffuse gastric cancer: updated clinical guidelines with an emphasis on germline <i>CDH1</i> mutation carriers","year":2015,"lang":"en","type":"review","venue":"Journal of Medical Genetics","topic":"Gastric Cancer Management and Outcomes","field":"Medicine","cited_by":564,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"Medical Research Council; ZonMw; Radboud Universitair Medisch Centrum; National Institute for Health and Care Research; Leids Universitair Medisch Centrum; Koninklijke Nederlandse Akademie van Wetenschappen; Universiteit Leiden; Cancer Research UK","keywords":"CDH1; Medicine; Breast cancer; Germline mutation; Cancer; Genetic testing; Signet ring cell carcinoma; Gastrectomy; Prophylactic Mastectomy; Invasive lobular carcinoma; Internal medicine; Oncology; Mastectomy; General surgery; Mutation; Genetics; Adenocarcinoma; Gene; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001955054,0.0009865218,0.001119638,0.002979757,0.0004292942,0.0009178668,0.001364017,0.002391483,0.004206017],"category_scores_gemma":[0.003801235,0.0003723816,0.001314532,0.002202069,0.0004742318,0.0008265679,0.001021118,0.002325637,0.002876478],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001301325,"about_ca_system_score_gemma":0.001930643,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01105255,"about_ca_topic_score_gemma":0.01762717,"domain_scores_codex":[0.9987496,0.0004344058,0.0003251446,0.00008461867,0.0002866806,0.0001195173],"domain_scores_gemma":[0.9975392,0.0004938155,0.000308906,0.00006583904,0.001349755,0.0002425371],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002168543,0.0001568674,0.005745841,0.002606396,0.0001081365,0.002412178,0.0002801538,0.001094385,0.001665035,0.002366315,0.6729832,0.3103647],"study_design_scores_gemma":[0.0001482136,0.000104205,0.01577989,0.006888442,0.0001758179,0.007278184,0.0002666697,0.0005746295,0.0003533635,0.002130881,0.9662442,0.00005556197],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.02049919,0.6555982,0.02978221,0.1264955,0.01607437,0.002522244,0.02004773,0.002461447,0.1265191],"genre_scores_gemma":[0.06890237,0.5312178,0.1571734,0.07743613,0.01155688,0.005098864,0.0800117,0.0006499169,0.06795294],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.01105255,"threshold_uncertainty_score":0.02197641,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1485630608455765,"score_gpt":0.4648712580982918,"score_spread":0.3163081972527153,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}