{"id":"W2103243010","doi":"10.1542/neo.10-4-e191","title":"Early Life Stress Induces Both Acute and Chronic Colonic Barrier Dysfunction","year":2009,"lang":"en","type":"article","venue":"NeoReviews","topic":"Stress Responses and Cortisol","field":"Neuroscience","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Medicine; Irritable bowel syndrome; Intestinal permeability; Barrier function; Disease; Maternal deprivation; Chronic stress; Inflammatory bowel disease; Internal medicine; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009744258,0.0003331111,0.0002562255,0.0001940974,0.0001431337,0.0002078177,0.0001041715,0.0002878768,0.001448679],"category_scores_gemma":[0.0001610624,0.0001099645,0.0001803667,0.00009186941,0.0003614064,0.0001107038,0.0002565804,0.0004902607,0.0001880354],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002455942,"about_ca_system_score_gemma":0.000167545,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004531918,"about_ca_topic_score_gemma":0.001117709,"domain_scores_codex":[0.9999008,0.0000225815,0.000006513104,0.00002018094,0.00002363934,0.00002628198],"domain_scores_gemma":[0.9998668,0.00001681508,0.00004971806,0.00001180852,0.00001485764,0.00003996662],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009952105,0.0001168412,0.006924795,0.000375832,0.0000646326,0.001429527,0.0002160148,0.00006489974,0.9607546,0.0002912929,0.0005943518,0.02817207],"study_design_scores_gemma":[0.00009400518,0.007290489,0.6471428,0.0003075091,0.0001466955,0.008826983,0.001357349,0.0003749309,0.3191142,0.001336363,0.01395646,0.00005227333],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9842921,0.01165247,0.001454332,0.0003105705,0.00009096808,0.00002022711,0.0002131847,0.00005697688,0.001909145],"genre_scores_gemma":[0.9877175,0.009531716,0.00085528,0.0001471838,0.00004129152,0.00003175862,0.0001918968,0.000007943479,0.001475337],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001448679,"threshold_uncertainty_score":0.004846334,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03020628191413747,"score_gpt":0.2897354680260378,"score_spread":0.2595291861119003,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}