{"id":"W2103246829","doi":"10.1084/jem.20111313","title":"Deregulation of TDP-43 in amyotrophic lateral sclerosis triggers nuclear factor κB–mediated pathogenic pathways","year":2011,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":335,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Hôpital de l'Enfant-Jésus; Centre hospitalier universitaire de Québec","funders":"Canadian Institutes of Health Research","keywords":"Amyotrophic lateral sclerosis; SOD1; Proinflammatory cytokine; Pathogenesis; NFKB1; Biology; Activator (genetics); Neurodegeneration; Denervation; Microglia; NF-κB; Cell biology; Cancer research; Molecular biology; Inflammation; Immunology; Transcription factor; Medicine; Signal transduction; Pathology; Endocrinology; Gene; Biochemistry; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002833385,0.0004377002,0.0003375034,0.0002409363,0.0002331274,0.0003064709,0.000115112,0.0003445321,0.001189883],"category_scores_gemma":[0.0002004426,0.0001620883,0.0002697889,0.000120851,0.0003527534,0.0002194613,0.0003535812,0.000422694,0.0003530389],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002741594,"about_ca_system_score_gemma":0.0001462264,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001926117,"about_ca_topic_score_gemma":0.0003086025,"domain_scores_codex":[0.9998028,0.00005131976,0.00001850747,0.00002827317,0.00005508653,0.00004407473],"domain_scores_gemma":[0.9998995,0.00001638279,0.00003121761,0.0000113277,0.00001073772,0.0000307829],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002057806,0.00004012135,0.0005016757,0.00006195719,0.00001133139,0.0006512642,0.00004164447,0.00005858782,0.9971659,0.0001212802,0.00004997437,0.001090553],"study_design_scores_gemma":[0.0001186079,0.0009927162,0.03443099,0.00005003348,0.00007995831,0.006259884,0.0002996086,0.001559106,0.9500204,0.00116342,0.005008235,0.0000170514],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964489,0.001923515,0.0007892411,0.0001069172,0.00002314744,0.00001002332,0.00006004001,0.00004436066,0.0005937831],"genre_scores_gemma":[0.9980105,0.0008368168,0.0004544871,0.00004164534,0.00001065334,0.00002073124,0.00008915827,0.000005667193,0.0005302361],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001189883,"threshold_uncertainty_score":0.003980577,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1124715084665669,"score_gpt":0.2962311521371991,"score_spread":0.1837596436706322,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}