{"id":"W2103251300","doi":"10.1016/s1470-2045(13)70110-4","title":"Methylation of the TERT promoter and risk stratification of childhood brain tumours: an integrative genomic and molecular study","year":2013,"lang":"en","type":"article","venue":"The Lancet Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":253,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; Hospital for Sick Children; Ontario Institute for Cancer Research; University Health Network; University of Toronto; SickKids Foundation","funders":"Canadian Institutes of Health Research; Terry Fox Foundation","keywords":"Methylation; Malignancy; CpG site; Cohort; DNA methylation; Biomarker; Oncology; Medicine; Pyrosequencing; Cancer; Internal medicine; Pathology; Biology; Cancer research; Gene; Genetics; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003007817,0.00006563563,0.0002426088,0.00002438904,0.00003226257,0.000005424186,0.00005512285,0.00003288364,0.00001133149],"category_scores_gemma":[0.00005976513,0.00002999944,0.00001858167,0.00005153616,0.0001017007,0.00002991973,0.00002645226,0.00008300362,6.696931e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002055443,"about_ca_system_score_gemma":0.00002844979,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002807908,"about_ca_topic_score_gemma":0.0001458891,"domain_scores_codex":[0.9992611,0.0003539262,0.0001456568,0.0001124783,0.00006008404,0.00006669036],"domain_scores_gemma":[0.9994328,0.0001113239,0.0001602898,0.000226799,0.00004777772,0.00002103691],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00007951942,0.00164942,0.7107931,0.00001824815,0.0002991087,0.0000027267,0.0180951,0.000005208519,0.2306174,0.0006425778,0.00009681789,0.03770082],"study_design_scores_gemma":[0.001607347,0.001551575,0.9737307,0.00001560844,0.0001841992,0.00001001849,0.001512619,0.0001393637,0.0199944,0.001215336,0.00001293219,0.00002590991],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941791,0.0002055619,0.0000183372,0.004206174,0.00001653786,0.001204694,0.000006658594,0.000004474011,0.0001584469],"genre_scores_gemma":[0.9995292,0.00003572537,0.0002143033,0.0001031502,0.00002628356,0.0000779773,0.000004528005,0.000004947741,0.000003888035],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2629376,"threshold_uncertainty_score":0.1223342,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01751296006933793,"score_gpt":0.3098881122709735,"score_spread":0.2923751522016356,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}