{"id":"W2103289668","doi":"10.18632/oncotarget.1497","title":"Drug resistance in multiple myeloma: latest findings and new concepts on molecular mechanisms","year":2013,"lang":"en","type":"review","venue":"Oncotarget","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":171,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Toronto General Hospital; University Health Network","funders":"Ministry of Science and Technology of the People's Republic of China; Cancer Research Society","keywords":"Multiple myeloma; Hematology; Medicine; Drug resistance; Oncology; Cancer; Pomalidomide; Cancer research; Internal medicine; Bortezomib; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002226399,0.000623467,0.001889722,0.0003585601,0.00007750699,0.0000605875,0.0002086616,0.0003367897,0.0003077879],"category_scores_gemma":[0.0003954433,0.0004736366,0.0002776565,0.000360116,0.000085477,0.00008171238,0.0001165967,0.0006777645,0.0006935867],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003994488,"about_ca_system_score_gemma":0.0004960653,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002857468,"about_ca_topic_score_gemma":0.0002047052,"domain_scores_codex":[0.9972104,0.0001708088,0.0005684558,0.0008179611,0.000546749,0.0006856149],"domain_scores_gemma":[0.9981896,0.0003747662,0.0001668424,0.000575425,0.00005632771,0.0006370133],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006889752,0.002054615,0.003183893,0.04043185,0.001731807,0.01110591,0.0008136711,8.472662e-7,0.0002994763,0.006833023,0.09164491,0.841211],"study_design_scores_gemma":[0.003471402,0.0001860147,0.0005405042,0.01377755,0.0002227583,0.00003430892,0.00001174701,0.0000102196,0.00009338841,0.0004703215,0.9807578,0.0004239421],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001680488,0.9927437,0.00002156162,0.0004430858,0.000115563,0.002569363,0.00006726036,0.00006210132,0.002296913],"genre_scores_gemma":[0.0009478159,0.9733643,0.007505532,0.0001526213,0.00009008225,0.0003013249,0.0004658951,0.0001216591,0.01705077],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8891129,"threshold_uncertainty_score":0.9997715,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05141101826830751,"score_gpt":0.3533042468832884,"score_spread":0.3018932286149809,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}