{"id":"W2103315577","doi":"10.1016/j.str.2014.10.017","title":"Molecular Basis of Histone Tail Recognition by Human TIP5 PHD Finger and Bromodomain of the Chromatin Remodeling Complex NoRC","year":2014,"lang":"en","type":"article","venue":"Structure","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Department of Biochemistry, University of Cambridge; Deutsches Elektronen-Synchrotron; Biotechnology and Biological Sciences Research Council; Directorate for Biological Sciences; Ontario Ministry of Economic Development and Innovation; Ministero dello Sviluppo Economico; Diamond Light Source; Genome Canada; Wellcome Trust; GlaxoSmithKline; European Commission; Pfizer; Eli Lilly and Company","keywords":"Bromodomain; PHD finger; Chromatin remodeling; Histone; Chromatin; Nucleosome; Zinc finger; Histone code; Biology; Histone-modifying enzymes; Histone H3; Cell biology; Genetics; Acetylation; Computational biology; Transcription factor; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007252847,0.0001928054,0.0001904115,0.00007627445,0.0002433525,0.0003295251,0.000459939,0.0002725397,0.001096843],"category_scores_gemma":[0.000164143,0.0001666564,0.0001751858,0.00007231651,0.000213701,0.0001846861,0.0002338572,0.0002738728,0.0005005653],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005618693,"about_ca_system_score_gemma":0.0002490492,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001650424,"about_ca_topic_score_gemma":0.001552143,"domain_scores_codex":[0.999933,0.000006624445,0.000003730144,0.00001975387,0.00002255519,0.00001435891],"domain_scores_gemma":[0.9999415,0.00000766981,0.00001302133,0.000005644306,0.000008668369,0.00002353475],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003553618,0.00004048234,0.003516782,0.0001101923,0.00002122688,0.0003641083,0.00004709501,0.001275604,0.9902623,0.001343833,0.0002231233,0.002439951],"study_design_scores_gemma":[0.0001298111,0.0001755975,0.04641796,0.00001842428,0.00003928209,0.001038978,0.0001518174,0.03252337,0.9116392,0.001303342,0.006532104,0.0000302169],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942335,0.0008136879,0.003006496,0.0001290527,0.00001486307,0.00001295021,0.0002668589,0.00005445955,0.001468096],"genre_scores_gemma":[0.9979672,0.0001173489,0.0008942144,0.00003115894,0.000003055911,0.000004110696,0.0004654252,0.000005884483,0.0005115868],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001650424,"threshold_uncertainty_score":0.0040766,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008043991533162502,"score_gpt":0.2306735437059893,"score_spread":0.2226295521728268,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}