{"id":"W2103338840","doi":"10.1093/hmg/ddp178","title":"Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell function","year":2009,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":274,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Center for Research Resources; National Institute of Diabetes and Digestive and Kidney Diseases; Universität Bremen; East China Institute of Technology; Deutsche Forschungsgemeinschaft; European Foundation for the Study of Diabetes","keywords":"Endocrinology; Internal medicine; TCF7L2; Biology; Downregulation and upregulation; Receptor; Glucagon; Insulin; Type 2 diabetes; Gastric inhibitory polypeptide; Islet; Beta cell; Diabetes mellitus; Medicine; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001243368,0.0004978044,0.0003009083,0.0007947891,0.0001837017,0.0003589829,0.0001473605,0.0005274442,0.001700601],"category_scores_gemma":[0.0001495012,0.000168725,0.0003116142,0.0004145089,0.0002713739,0.0001212919,0.0001419185,0.0006548008,0.0004175565],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002204936,"about_ca_system_score_gemma":0.000103922,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000500035,"about_ca_topic_score_gemma":0.0005586689,"domain_scores_codex":[0.9998572,0.00001428719,0.00001263342,0.00004184844,0.00004463516,0.00002944009],"domain_scores_gemma":[0.9998185,0.00001953114,0.00006944851,0.00001105215,0.00002329035,0.00005818267],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0008293713,0.00004456142,0.007388042,0.00007286126,0.00005903164,0.000416839,0.00002635171,0.00003054057,0.9885442,0.00002743638,0.0001890992,0.002371639],"study_design_scores_gemma":[0.0001716086,0.0006044364,0.4781167,0.00003380425,0.0002316395,0.007679385,0.0002118119,0.001161969,0.5062526,0.0002112933,0.005296652,0.00002822773],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921566,0.004243247,0.001541726,0.0001791461,0.00004922512,0.00001072371,0.0008876288,0.0001043009,0.0008273358],"genre_scores_gemma":[0.9919388,0.001692786,0.001707145,0.0002322906,0.00005230091,0.00006175885,0.002266892,0.00005241855,0.001995499],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001700601,"threshold_uncertainty_score":0.005689085,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0123428554113545,"score_gpt":0.2246317987971672,"score_spread":0.2122889433858127,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}