{"id":"W2103371583","doi":"10.1086/320876","title":"Need for Alternative Trial Designs and Evaluation Strategies for Therapeutic Studies of Invasive Mycoses","year":2001,"lang":"en","type":"article","venue":"Clinical Infectious Diseases","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"Manitoba Health","funders":"","keywords":"Medicine; Intensive care medicine; Antifungal; Clinical trial; Randomized controlled trial; Clinical study design; Invasive candidiasis; Risk analysis (engineering); Surgery; Fluconazole; Pathology; Dermatology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.6636953,0.003919996,0.01335505,0.005084442,0.002081718,0.01019677,0.006083891,0.01218675,0.01044651],"category_scores_gemma":[0.6946598,0.002275035,0.007853221,0.008056148,0.007383369,0.01148819,0.004435363,0.01475639,0.002113607],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.005579216,"about_ca_system_score_gemma":0.0108104,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007276461,"about_ca_topic_score_gemma":0.0009696757,"domain_scores_codex":[0.1763937,0.7614992,0.03600595,0.005135888,0.02007262,0.0008927443],"domain_scores_gemma":[0.2533433,0.6275606,0.03172779,0.053335,0.03004245,0.003990962],"domain_codex":"methods","domain_gemma":"methods","domain_candidate":"methods","domain_consensus":"methods","study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.07484449,0.002837493,0.007299795,0.02756898,0.01763872,0.0007264394,0.002108427,0.006842769,0.002124965,0.2758668,0.02286414,0.559277],"study_design_scores_gemma":[0.1768504,0.03040701,0.009125262,0.02368221,0.0224251,0.001073331,0.0010556,0.04334303,0.006066961,0.517621,0.1670433,0.001306871],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.01353452,0.05141876,0.6978946,0.08466526,0.03148435,0.1047429,0.001368767,0.0009377517,0.0139532],"genre_scores_gemma":[0.05038128,0.007537315,0.7977291,0.0279593,0.006912317,0.107108,0.0003617882,0.0002376458,0.001773246],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.3363047,"threshold_uncertainty_score":0.4147236,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3458958500988578,"score_gpt":0.5189002794365981,"score_spread":0.1730044293377403,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}