{"id":"W2103382198","doi":"10.1534/genetics.107.080408","title":"Synthetic Lethal Interactions Identify Phenotypic “Interologs” of the Spindle Assembly Checkpoint Components","year":2007,"lang":"en","type":"article","venue":"Genetics","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Biology; Caenorhabditis elegans; RNA interference; Phenotype; Genetics; Genetic screen; Spindle checkpoint; Mutant; Enhancer; Synthetic lethality; Mutation; Function (biology); Cell biology; Kinetochore; Gene; Chromosome; Transcription factor; RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000231718,0.0001451288,0.0001362627,0.00004058254,0.00007846348,0.00001425576,0.0003704929,0.0001269252,0.000021732],"category_scores_gemma":[0.00004542449,0.0001210096,0.0001689632,0.00008016114,0.0001210514,0.000002155317,0.0002691279,0.000141354,0.0000174905],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002014454,"about_ca_system_score_gemma":0.00003243732,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002109977,"about_ca_topic_score_gemma":0.0002963273,"domain_scores_codex":[0.9989625,0.00004997473,0.0003360922,0.0002544594,0.0001324584,0.0002645354],"domain_scores_gemma":[0.9991149,0.00001461378,0.0001585217,0.0005598692,0.00009384966,0.00005825339],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002942122,0.0001052614,0.004579183,0.00001479712,0.0000571587,0.000001027364,0.00006820275,0.00008359999,0.9935012,0.00003386099,0.0003532313,0.001173058],"study_design_scores_gemma":[0.0002874113,0.0001020266,0.06270833,0.00002635016,0.00004479102,0.00004519989,0.00009201677,0.0001409563,0.926209,0.00006184672,0.01014767,0.0001344387],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9875718,0.0002853822,0.01026501,0.0001032808,0.0006633888,0.0001745386,0.00001752667,0.000007333757,0.0009117308],"genre_scores_gemma":[0.9981542,0.00006278513,0.0009658431,0.0001741627,0.0001527748,0.0000046802,0.00003039705,0.00002315743,0.0004320247],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06729224,"threshold_uncertainty_score":0.4934627,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01539156528643728,"score_gpt":0.2782870879291316,"score_spread":0.2628955226426944,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}