{"id":"W2103382198","doi":"10.1534/genetics.107.080408","title":"Synthetic Lethal Interactions Identify Phenotypic “Interologs” of the Spindle Assembly Checkpoint Components","year":2007,"lang":"en","type":"article","venue":"Genetics","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Biology; Caenorhabditis elegans; RNA interference; Phenotype; Genetics; Genetic screen; Spindle checkpoint; Mutant; Enhancer; Synthetic lethality; Mutation; Function (biology); Cell biology; Kinetochore; Gene; Chromosome; Transcription factor; RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001084168,0.0006947512,0.0001235038,0.0002875857,0.000227073,0.0002232484,0.000237767,0.0003086419,0.002870121],"category_scores_gemma":[0.0001451328,0.0001818297,0.0001766018,0.00006525216,0.0003404921,0.0001169715,0.0005490101,0.0006941384,0.0004444969],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003634638,"about_ca_system_score_gemma":0.000161085,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003956796,"about_ca_topic_score_gemma":0.001463028,"domain_scores_codex":[0.9997601,0.00003648649,0.00001419303,0.00006190553,0.000085336,0.000042053],"domain_scores_gemma":[0.9998122,0.000038404,0.00005752881,0.00002472,0.000009492195,0.00005760254],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005103875,0.00001856295,0.0002728781,0.00001342513,0.00000516567,0.0001544883,0.000008948072,0.0000535894,0.998533,0.0001467535,0.00004546937,0.0006966855],"study_design_scores_gemma":[0.00003470822,0.000148681,0.01449576,0.0000105564,0.00003170601,0.001860764,0.00003998547,0.001018463,0.9779972,0.0001422451,0.004210838,0.000008991564],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908245,0.0007029217,0.004344555,0.0001383094,0.00004046042,0.00002672643,0.0002826084,0.0001764145,0.003463484],"genre_scores_gemma":[0.9961578,0.0001466173,0.001210393,0.00004558376,0.000005521338,0.00002015446,0.0002603883,0.00003195921,0.002121762],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002870121,"threshold_uncertainty_score":0.009601474,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01539156528643728,"score_gpt":0.2782870879291316,"score_spread":0.2628955226426944,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}