{"id":"W2103394810","doi":"10.1002/cncr.21227","title":"Phase II study of tariquidar, a selective P‐glycoprotein inhibitor, in patients with chemotherapy‐resistant, advanced breast carcinoma","year":2005,"lang":"en","type":"article","venue":"Cancer","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":300,"is_retracted":false,"has_abstract":true,"ca_institutions":"QLT (Canada)","funders":"National Cancer Institute","keywords":"Medicine; Chemotherapy; Oncology; Internal medicine; Breast carcinoma; Phases of clinical research; Breast cancer; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008346965,0.0008638753,0.002071027,0.0002614051,0.0002818747,0.0007017948,0.0006129374,0.0007120096,0.001680369],"category_scores_gemma":[0.000770401,0.0003908068,0.0006343488,0.0003380705,0.0005654322,0.000479175,0.0002543118,0.001658813,0.0004653752],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006306851,"about_ca_system_score_gemma":0.001166106,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007845807,"about_ca_topic_score_gemma":0.001585952,"domain_scores_codex":[0.9997317,0.0001196654,0.00001604926,0.00004578445,0.00002928559,0.00005738008],"domain_scores_gemma":[0.9995023,0.0001008194,0.00009702615,0.00003978961,0.00003706579,0.0002230424],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5637497,0.08848723,0.04066972,0.001126683,0.001657313,0.001253704,0.0007619371,0.006349592,0.1192469,0.0003519647,0.004212589,0.1721327],"study_design_scores_gemma":[0.408847,0.5393585,0.03223684,0.00003547654,0.0006986589,0.001160634,0.0001579055,0.003218396,0.009796305,0.0001831984,0.00427034,0.00003676652],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996382,0.001286052,0.0003263497,0.0002041985,0.00004649798,0.0009078629,0.0002967331,0.00003597464,0.0005142763],"genre_scores_gemma":[0.9941052,0.001262157,0.001043953,0.0004400457,0.0001139506,0.0009965738,0.001134185,0.0000158559,0.0008879233],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002071027,"threshold_uncertainty_score":0.005621433,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004870553676997753,"score_gpt":0.2457429134654044,"score_spread":0.2408723597884066,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}