{"id":"W2103433909","doi":"10.1126/science.1224026","title":"Mycobacterial Disease and Impaired IFN-γ Immunity in Humans with Inherited ISG15 Deficiency","year":2012,"lang":"en","type":"article","venue":"Science","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":566,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University","funders":"National Center for Advancing Translational Sciences; National Institute of Allergy and Infectious Diseases; National Cancer Institute","keywords":"ISG15; Immunology; Immunity; Biology; Tuberculosis; Disease; Virology; Medicine; Immune system; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005651677,0.0001111478,0.000124189,0.000164731,0.0002916025,0.0000336213,0.0002531491,0.00004765596,0.0002124594],"category_scores_gemma":[0.0001584312,0.00008175606,0.00001729614,0.0003465052,0.001268776,0.0004138903,0.0001403979,0.0001567741,0.00006926585],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004402816,"about_ca_system_score_gemma":0.0001544871,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009202404,"about_ca_topic_score_gemma":0.00002892852,"domain_scores_codex":[0.9990031,0.0001295635,0.000138128,0.0001911543,0.0000442417,0.0004937954],"domain_scores_gemma":[0.9995752,0.00004370891,0.00004222723,0.0002434254,0.00004127774,0.00005414645],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0008230786,0.0001770145,0.08579619,0.000007332749,0.000004665041,0.000002293562,0.002089612,3.501732e-7,0.9097777,0.000379636,0.00004304432,0.0008990585],"study_design_scores_gemma":[0.0006963977,0.0002047363,0.9687577,0.00003205072,0.000007830577,0.00002373056,0.0005056559,0.000002353642,0.02789764,0.00002116561,0.001706404,0.0001443561],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967934,0.002003341,0.00001520312,0.00006625549,0.0004177172,0.0001277369,0.000007863302,0.00003017394,0.0005382436],"genre_scores_gemma":[0.9994151,0.00002810622,0.00002750545,0.00007731457,0.00001002568,0.000009342302,0.000005863282,0.000005092272,0.000421645],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8829615,"threshold_uncertainty_score":0.4674858,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01408680664435792,"score_gpt":0.2516552985536529,"score_spread":0.237568491909295,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}