{"id":"W2103433909","doi":"10.1126/science.1224026","title":"Mycobacterial Disease and Impaired IFN-γ Immunity in Humans with Inherited ISG15 Deficiency","year":2012,"lang":"en","type":"article","venue":"Science","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":566,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University","funders":"National Center for Advancing Translational Sciences; National Institute of Allergy and Infectious Diseases; National Cancer Institute","keywords":"ISG15; Immunology; Immunity; Biology; Tuberculosis; Disease; Virology; Medicine; Immune system; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001946804,0.001137272,0.0005110034,0.0009957136,0.0005925995,0.0004336075,0.0001475986,0.000860041,0.00246367],"category_scores_gemma":[0.0004851267,0.0003353701,0.0002810013,0.0003754375,0.0009046028,0.0003298806,0.0003919543,0.0004127605,0.0003683667],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001707283,"about_ca_system_score_gemma":0.0001696476,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007298075,"about_ca_topic_score_gemma":0.0006465052,"domain_scores_codex":[0.9998311,0.0000308355,0.00002865916,0.00005713868,0.0000259766,0.00002637996],"domain_scores_gemma":[0.9998272,0.00004111523,0.00006361915,0.00001954692,0.00001374309,0.00003480076],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003850515,0.0004952876,0.4162259,0.0003774748,0.0003425111,0.2399531,0.002179441,0.0005699224,0.3007092,0.001660653,0.001516381,0.03211971],"study_design_scores_gemma":[0.0001758921,0.001991522,0.3621802,0.0001451182,0.0004208338,0.5847371,0.0008503003,0.001246113,0.04159644,0.001842699,0.004753076,0.00006065835],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975841,0.0005535221,0.000494155,0.0001158256,0.000009612641,0.00001197267,0.00009148279,0.00003402227,0.001105307],"genre_scores_gemma":[0.9989241,0.0002349322,0.0003338236,0.00007695844,0.00001623625,0.00000473423,0.00007749955,0.000008083405,0.000323693],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00246367,"threshold_uncertainty_score":0.008241773,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01408680664435792,"score_gpt":0.2516552985536529,"score_spread":0.237568491909295,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}