{"id":"W2103439634","doi":"10.4269/ajtmh.14-0031","title":"Polymorphisms in Plasmodium falciparum Chloroquine Resistance Transporter and Multidrug Resistance 1 Genes: Parasite Risk Factors That Affect Treatment Outcomes for P. falciparum Malaria After Artemether-Lumefantrine and Artesunate-Amodiaquine","year":2014,"lang":"en","type":"article","venue":"American Journal of Tropical Medicine and Hygiene","topic":"Malaria Research and Control","field":"Medicine","cited_by":304,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Faculty of Tropical Medicine, Mahidol University; Centers for Disease Control and Prevention; Muhimbili University of Health and Allied Sciences; Jimma University; Sveriges Lantbruksuniversitet; Department of Medicine, University of California, San Francisco; Karolinska Institutet; Drugs for Neglected Diseases initiative; Charles Darwin University; University of Oxford; University of Health and Allied Sciences; Mahidol University; University College London; University of Washington; Menzies School of Health Research; University of California, San Francisco; King Fahd University of Petroleum and Minerals; Wellcome Trust; National Institutes of Health; Faculty of Medicine, University of British Columbia; National Institute of Allergy and Infectious Diseases; London School of Hygiene and Tropical Medicine","keywords":"Amodiaquine; Plasmodium falciparum; Malaria; Artemether/lumefantrine; Artesunate; Chloroquine; Biology; Drug resistance; Artemether; Artemisinin; Lumefantrine; Parasite hosting; Multiple drug resistance; Mefloquine; Virology; Apicoplast; Pharmacology; Medicine; Apicomplexa; Immunology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005395783,0.0004486745,0.001769916,0.0004013075,0.0001026048,0.00002875813,0.0001183472,0.00009642237,0.00004218943],"category_scores_gemma":[0.0004158342,0.0002694377,0.0001821817,0.0002094856,0.0007759403,0.0001541728,0.0000234616,0.0003708276,5.266371e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007905954,"about_ca_system_score_gemma":0.00006110887,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003363279,"about_ca_topic_score_gemma":0.00121468,"domain_scores_codex":[0.9973446,0.0002407648,0.0007975462,0.0004844743,0.0004902931,0.0006423097],"domain_scores_gemma":[0.9973668,0.001022269,0.0004618872,0.0003099548,0.0001242851,0.0007147319],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01242513,0.0002728098,0.961882,0.0001250686,0.0004321147,0.0001989957,0.0008174641,0.000002265258,0.001525305,0.0001969546,0.00008666456,0.02203526],"study_design_scores_gemma":[0.01599862,0.007302911,0.969696,0.0003819901,0.0005598451,0.00005608672,0.0004659579,0.0002401602,0.0004403033,0.000188627,0.004419945,0.0002495258],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9698221,0.004397999,0.002516603,0.0223592,0.0001124461,0.0006884583,0.00005102131,0.00001470272,0.00003745396],"genre_scores_gemma":[0.9936174,0.003304424,0.001782947,0.0004442291,0.0002261649,0.00007183944,0.00001048664,0.00003888484,0.0005036916],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02379522,"threshold_uncertainty_score":0.9999758,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01854947287217903,"score_gpt":0.2888017731095698,"score_spread":0.2702523002373908,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}