{"id":"W2103439634","doi":"10.4269/ajtmh.14-0031","title":"Polymorphisms in Plasmodium falciparum Chloroquine Resistance Transporter and Multidrug Resistance 1 Genes: Parasite Risk Factors That Affect Treatment Outcomes for P. falciparum Malaria After Artemether-Lumefantrine and Artesunate-Amodiaquine","year":2014,"lang":"en","type":"article","venue":"American Journal of Tropical Medicine and Hygiene","topic":"Malaria Research and Control","field":"Medicine","cited_by":304,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Faculty of Tropical Medicine, Mahidol University; Centers for Disease Control and Prevention; Muhimbili University of Health and Allied Sciences; Jimma University; Sveriges Lantbruksuniversitet; Department of Medicine, University of California, San Francisco; Karolinska Institutet; Drugs for Neglected Diseases initiative; Charles Darwin University; University of Oxford; University of Health and Allied Sciences; Mahidol University; University College London; University of Washington; Menzies School of Health Research; University of California, San Francisco; King Fahd University of Petroleum and Minerals; Wellcome Trust; National Institutes of Health; Faculty of Medicine, University of British Columbia; National Institute of Allergy and Infectious Diseases; London School of Hygiene and Tropical Medicine","keywords":"Amodiaquine; Plasmodium falciparum; Malaria; Artemether/lumefantrine; Artesunate; Chloroquine; Biology; Drug resistance; Artemether; Artemisinin; Lumefantrine; Parasite hosting; Multiple drug resistance; Mefloquine; Virology; Apicoplast; Pharmacology; Medicine; Apicomplexa; Immunology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001487816,0.0001823031,0.0004078827,0.0002688181,0.0002073377,0.0002933376,0.0001530878,0.0003364025,0.0009252196],"category_scores_gemma":[0.002222958,0.0001208824,0.0004613688,0.0005575361,0.0002525792,0.0002799354,0.0001951411,0.000450453,0.00009525209],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001792461,"about_ca_system_score_gemma":0.0002129919,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008220871,"about_ca_topic_score_gemma":0.001151638,"domain_scores_codex":[0.9992353,0.000364327,0.00006598415,0.0001454482,0.0001191959,0.00006967933],"domain_scores_gemma":[0.9987403,0.0004519002,0.0005580373,0.00008648223,0.00006456953,0.00009887494],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004827914,0.000148523,0.9802738,0.0000728752,0.0004610143,0.0001288973,0.00008997229,0.000316839,0.002391694,0.00004486385,0.0001576905,0.01108594],"study_design_scores_gemma":[0.0000767289,0.0002951221,0.9987935,0.000004762582,0.0001042707,0.0001370916,0.00001868692,0.0002187936,0.0001945407,0.00002489859,0.000129477,0.000002197766],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987387,0.0006542414,0.0001691754,0.00004538246,0.00000239592,0.00001393524,0.0001660929,0.00000282822,0.000207313],"genre_scores_gemma":[0.9996365,0.00007582715,0.00006710371,0.00001404945,0.000006717955,0.000009015364,0.0001316024,0.000001156966,0.00005808178],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001487816,"threshold_uncertainty_score":0.007868469,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01854947287217903,"score_gpt":0.2888017731095698,"score_spread":0.2702523002373908,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}