{"id":"W2103505699","doi":"10.1101/sqb.2007.72.072","title":"A Circadian Clock in<i>Neurospora:</i>How Genes and Proteins Cooperate to Produce a Sustained, Entrainable, and Compensated Biological Oscillator with a Period of about a Day","year":2007,"lang":"en","type":"review","venue":"Cold Spring Harbor Symposia on Quantitative Biology","topic":"Circadian rhythm and melatonin","field":"Neuroscience","cited_by":84,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; Fonds de Recherche du Québec - Santé; National Institutes of Health; Dartmouth College","keywords":"Neurospora; Circadian clock; Circadian rhythm; Entrainment (biomusicology); Biology; Bacterial circadian rhythms; Cell biology; Transcription factor; Gene; Transcription (linguistics); Negative feedback; Genetics; Oscillating gene; Casein kinase 1; Neurospora crassa; Phosphorylation; Protein kinase A; Rhythm; Neuroscience; Internal medicine; Physics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006957724,0.0007601417,0.002075999,0.0008004518,0.0001778708,0.0001024372,0.0003351131,0.0004652194,0.000003933543],"category_scores_gemma":[0.001025472,0.0005696242,0.0001174172,0.001245777,0.0009209634,0.00008567178,0.0001856935,0.0005891313,0.000009331444],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001370312,"about_ca_system_score_gemma":0.0004720396,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003359298,"about_ca_topic_score_gemma":0.00002741363,"domain_scores_codex":[0.9956284,0.0008433482,0.000702605,0.001739112,0.000174273,0.0009123184],"domain_scores_gemma":[0.9977738,0.0007168229,0.0004855834,0.0004757378,0.0001649575,0.0003830636],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002437336,0.0001323311,0.001348122,0.002162336,0.00004335073,0.0004561428,0.0004100568,0.000001791679,0.04630019,0.9448689,0.000001633071,0.004031384],"study_design_scores_gemma":[0.001114645,0.003450706,0.002942929,0.004605414,0.00008885112,0.00009510337,0.00009236678,0.00002443556,0.006520586,0.000005087878,0.9800923,0.0009675192],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.1987677,0.796219,0.00007203274,0.0002202122,0.0001316608,0.004325539,0.0001535536,0.00006355443,0.00004680888],"genre_scores_gemma":[0.2206542,0.7778257,0.0005902825,0.0002711482,0.00006456239,0.0004285634,0.000005145545,0.00009663132,0.00006381838],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9800907,"threshold_uncertainty_score":0.9996755,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06174999197884796,"score_gpt":0.3157379666973448,"score_spread":0.2539879747184968,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}