{"id":"W2103510620","doi":"10.1038/clpt.2008.51","title":"Lazarus's Gate: Challenges and Potential of Epigenetic Reprogramming of Somatic Cells","year":2008,"lang":"en","type":"review","venue":"Clinical Pharmacology & Therapeutics","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Reprogramming; Somatic cell nuclear transfer; Somatic cell; Epigenetics; Induced pluripotent stem cell; Biology; Cell biology; Biotechnology; Genetics; Cell; Embryonic stem cell; Embryo; Blastocyst; Gene; Embryogenesis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001537498,0.0005460076,0.0009742382,0.001003395,0.0004593114,0.001487153,0.0009513766,0.00159993,0.002230189],"category_scores_gemma":[0.0009213502,0.0001509648,0.0004145225,0.0008209117,0.002426812,0.003384494,0.001028294,0.003477804,0.001818191],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008034325,"about_ca_system_score_gemma":0.000957267,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005985789,"about_ca_topic_score_gemma":0.0007979604,"domain_scores_codex":[0.999651,0.000111186,0.00002996885,0.00005302198,0.0001320605,0.00002283415],"domain_scores_gemma":[0.9995776,0.000280286,0.00002495633,0.00002708955,0.00005219,0.00003794525],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008034336,0.00004145013,0.0001443973,0.003243974,0.00005251133,0.0005857369,0.0003214889,0.0005371035,0.00392141,0.1348558,0.04295081,0.813265],"study_design_scores_gemma":[0.00001130179,0.00006862961,0.0001609355,0.0007058677,0.00001559973,0.001020617,0.00009379402,0.0001106073,0.001450863,0.03526749,0.9610772,0.00001714912],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004334539,0.9861323,0.002047115,0.004934151,0.001263355,0.000004432043,0.000009629112,0.00002830424,0.005147295],"genre_scores_gemma":[0.005444834,0.9841608,0.001310556,0.003110923,0.001113758,0.00001279588,0.00001428223,0.000009846258,0.004822164],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002230189,"threshold_uncertainty_score":0.008131206,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1418871195795686,"score_gpt":0.4420112161389818,"score_spread":0.3001240965594132,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}