{"id":"W2103513032","doi":"10.1016/j.bmcl.2015.11.008","title":"Suppression of store overload-induced calcium release by hydroxylated metabolites of carvedilol","year":2015,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"Libin Cardiovascular Institute of Alberta; University of Calgary","funders":"University of Calgary; Natural Sciences and Engineering Research Council of Canada; Heart and Stroke Foundation of Canada","keywords":"Carvedilol; Ryanodine receptor 2; Chemistry; Ryanodine receptor; Calcium; Pharmacology; Calcium channel; Hydroxylation; HEK 293 cells; Heart failure; Biochemistry; Internal medicine; Receptor; Enzyme; Biology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001872282,0.0003463697,0.0003491389,0.0002378456,0.000182081,0.0002362518,0.0003976467,0.0003269039,0.00167141],"category_scores_gemma":[0.0002962637,0.0001778669,0.0003240148,0.0001102653,0.0002624789,0.0003335541,0.0001999656,0.0007425574,0.0002734016],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001718709,"about_ca_system_score_gemma":0.0003138204,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00041796,"about_ca_topic_score_gemma":0.0005386843,"domain_scores_codex":[0.9998982,0.0000220551,0.00001045629,0.00001136046,0.00001503382,0.00004286357],"domain_scores_gemma":[0.9998216,0.00005530154,0.00003027291,0.00002912297,0.00002045683,0.00004316786],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004903902,0.0001634687,0.0002216041,0.00006887152,0.00002409798,0.0002251288,0.00006246704,0.0001270198,0.9887347,0.0002805303,0.00009105939,0.005097183],"study_design_scores_gemma":[0.0001850022,0.001128281,0.0008120765,0.000004012528,0.00003002004,0.0001689134,0.00002463252,0.0005794607,0.9962243,0.00006312368,0.000772661,0.000007454641],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964257,0.0009765911,0.001305504,0.0001225101,0.00003646753,0.00002924631,0.0001793415,0.00006453495,0.0008601078],"genre_scores_gemma":[0.9974221,0.0005597877,0.0008545069,0.00004059593,0.00002286144,0.00002007845,0.0002877566,0.00001199445,0.0007803284],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00167141,"threshold_uncertainty_score":0.005591393,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01743716834939601,"score_gpt":0.255939658917967,"score_spread":0.238502490568571,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}