{"id":"W2103524426","doi":"10.1139/v02-087","title":"Hydroxynitrile lyase-catalyzed addition of HCN to 4-substituted cyclohexanones: stereoselective preparation of tetronic acids","year":2002,"lang":"en","type":"article","venue":"Canadian Journal of Chemistry","topic":"Enzyme Structure and Function","field":"Materials Science","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Bayer","keywords":"Stereoselectivity; Chemistry; Isomerization; Cyanohydrin; Catalysis; Stereochemistry; Selectivity; Organic chemistry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002168682,0.0005907718,0.0002829708,0.0002565097,0.0001496541,0.0001772117,0.0002181489,0.0002803951,0.001713726],"category_scores_gemma":[0.0001766858,0.0001542013,0.0002335254,0.0002505615,0.0001845659,0.0003248147,0.0002787162,0.0004739749,0.0009909208],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004032716,"about_ca_system_score_gemma":0.0004042273,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007214466,"about_ca_topic_score_gemma":0.002383607,"domain_scores_codex":[0.9998323,0.00002557824,0.00001665453,0.00003393093,0.0000370174,0.0000544067],"domain_scores_gemma":[0.9998409,0.00001985026,0.00003241729,0.00002628165,0.00003183837,0.00004874116],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000752365,0.00001849934,0.00009632912,0.00004422634,0.00000605993,0.0000537265,0.00002656499,0.00007676907,0.9972647,0.0001247753,0.00002577393,0.002187263],"study_design_scores_gemma":[0.000003412509,0.00006597973,0.0002501844,0.000001546909,0.000003053241,0.00003208161,0.000005639126,0.00004473349,0.9986045,0.00001057675,0.000975969,0.00000239651],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9718719,0.002369962,0.01321084,0.000118921,0.00009882502,0.0001722627,0.0009922464,0.0001724152,0.01099262],"genre_scores_gemma":[0.9777468,0.001872871,0.009932936,0.00005327121,0.00001514461,0.00006983483,0.001224709,0.00006443913,0.009020082],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001713726,"threshold_uncertainty_score":0.005732954,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009199133690362881,"score_gpt":0.2110032861650834,"score_spread":0.2018041524747206,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}