{"id":"W2103580640","doi":"10.1124/dmd.107.015271","title":"Possible Bioactivation Pathways of Lamotrigine","year":2007,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Tuberculosis Research and Epidemiology","field":"Medicine","cited_by":49,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Lamotrigine; Chemistry; Metabolite; Microsome; Biochemistry; Anticonvulsant; Sulfation; Sulfotransferase; Lipid peroxidation; Stereochemistry; Pharmacology; Enzyme; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006794685,0.0005310716,0.000336624,0.0009803842,0.0004214577,0.001218706,0.0006093836,0.0007723229,0.005504722],"category_scores_gemma":[0.001537706,0.0003960147,0.0006845588,0.0005015958,0.0004859336,0.0006993062,0.000371326,0.0007026942,0.0007532243],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001099047,"about_ca_system_score_gemma":0.0007771853,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003047222,"about_ca_topic_score_gemma":0.001510667,"domain_scores_codex":[0.9995784,0.0002197735,0.0000280331,0.00007139114,0.0000372497,0.00006506532],"domain_scores_gemma":[0.9994028,0.0002454488,0.0001606962,0.00007485208,0.00007445026,0.00004179732],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0120355,0.0005257007,0.13516,0.001000102,0.001152183,0.008072234,0.001598632,0.005986299,0.6654189,0.03981553,0.001773635,0.1274613],"study_design_scores_gemma":[0.000540334,0.002634868,0.1814055,0.0001929831,0.001172502,0.02222531,0.001400987,0.01993487,0.7098905,0.03135318,0.02910618,0.0001428899],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9378536,0.02769838,0.02116713,0.002093299,0.00005693535,0.0001507485,0.001104908,0.0001866463,0.009688342],"genre_scores_gemma":[0.9897156,0.003476086,0.002897988,0.0001904532,0.0000282877,0.00005573577,0.0005860424,0.00001596741,0.003033701],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005504722,"threshold_uncertainty_score":0.01841515,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01720556687234154,"score_gpt":0.2983647555630278,"score_spread":0.2811591886906863,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}