{"id":"W2103580640","doi":"10.1124/dmd.107.015271","title":"Possible Bioactivation Pathways of Lamotrigine","year":2007,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Tuberculosis Research and Epidemiology","field":"Medicine","cited_by":49,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Lamotrigine; Chemistry; Metabolite; Microsome; Biochemistry; Anticonvulsant; Sulfation; Sulfotransferase; Lipid peroxidation; Stereochemistry; Pharmacology; Enzyme; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006348745,0.00007621141,0.0002323314,0.000181021,0.00004567753,0.000004982524,0.00002520225,0.00005847959,0.00002836218],"category_scores_gemma":[0.0001160989,0.0000588106,0.0000515162,0.0001895667,0.00006887344,0.0001156754,0.00001633978,0.00009257265,0.000007090755],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001164789,"about_ca_system_score_gemma":0.0000223524,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001685535,"about_ca_topic_score_gemma":0.00001027527,"domain_scores_codex":[0.9992433,0.00004303183,0.0002249988,0.0001433969,0.0001463637,0.0001989266],"domain_scores_gemma":[0.999503,0.00009272793,0.00006051836,0.0001180387,0.00008625004,0.0001395371],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001545679,0.0004523252,0.05220699,0.0002943768,0.0001084187,0.00002542613,0.0006950913,0.00000365905,0.8026471,0.05857835,0.001755045,0.08168752],"study_design_scores_gemma":[0.001093341,0.00006967843,0.8690709,0.00004080903,0.00006666037,0.00002796778,0.0001393098,0.0001455715,0.1255714,0.001148786,0.00255589,0.00006973477],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918077,0.001839558,0.001982237,0.0009708497,0.00006843557,0.000166423,0.00001298001,0.00002514746,0.003126676],"genre_scores_gemma":[0.9979196,0.0004483844,0.0008851769,0.000350679,0.0001668565,0.000004083417,0.0001018352,0.000006971663,0.0001163932],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8168639,"threshold_uncertainty_score":0.2398227,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01720556687234154,"score_gpt":0.2983647555630278,"score_spread":0.2811591886906863,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}