{"id":"W2103621712","doi":"10.1093/intimm/dxn140","title":"IL-7 and the HIV Tat protein act synergistically to down-regulate CD127 expression on CD8 T cells","year":2009,"lang":"en","type":"article","venue":"International Immunology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa; Health Canada","funders":"","keywords":"Interleukin-7 receptor; STAT5; CD8; T cell; Molecular biology; STAT protein; Cell biology; Biology; Chemistry; Signal transduction; IL-2 receptor; Immune system; Immunology; STAT3","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001414596,0.000596183,0.0004957762,0.0002453784,0.0001234519,0.0003241888,0.00020105,0.0003765862,0.001604122],"category_scores_gemma":[0.0001572729,0.0001769288,0.0003949823,0.0001319046,0.0002485671,0.0002144898,0.0003696032,0.0007228805,0.0005469759],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002154735,"about_ca_system_score_gemma":0.0003337436,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001354986,"about_ca_topic_score_gemma":0.0004032259,"domain_scores_codex":[0.9995199,0.0000913703,0.00003301591,0.00005329196,0.0001443245,0.0001580652],"domain_scores_gemma":[0.9998366,0.00004567232,0.00003423539,0.00001412067,0.00001427949,0.00005507978],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002099589,0.00007619517,0.000200024,0.00005617776,0.00001063613,0.0000671904,0.00001432595,0.0001232736,0.9964584,0.0001115795,0.00007383104,0.002598343],"study_design_scores_gemma":[0.00005163136,0.001298013,0.003406551,0.00001350338,0.00004649476,0.0005542433,0.0000385612,0.001799955,0.98933,0.0000999171,0.003354754,0.000006334576],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9880764,0.005770729,0.002437707,0.000238847,0.0001061714,0.0000622046,0.0001736206,0.00008904911,0.003045262],"genre_scores_gemma":[0.9904405,0.001599245,0.004198372,0.0001852342,0.00008263309,0.00008835661,0.000340391,0.00002002702,0.003045207],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001604122,"threshold_uncertainty_score":0.005366266,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007660629165023957,"score_gpt":0.2564656014005041,"score_spread":0.2488049722354801,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}