{"id":"W2103634797","doi":"10.1128/aac.47.8.2545-2550.2003","title":"Subinhibitory Concentrations of the Deformylase Inhibitor Actinonin Increase Bacterial Release of Neutrophil-Activating Peptides: a New Approach to Antimicrobial Chemotherapy","year":2003,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children’s Health Research Institute","funders":"Medical Research Council; Stiftelsen för Strategisk Forskning","keywords":"Innate immune system; Antimicrobial peptides; Antimicrobial; Biochemistry; Biology; Peptide; Secretion; Microbiology; Escherichia coli; Receptor; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007693864,0.0003483862,0.0003300023,0.0001461936,0.0000867631,0.000196887,0.0001701822,0.0002132512,0.0008248448],"category_scores_gemma":[0.0001018182,0.00009736688,0.0001309164,0.0001082238,0.0001828477,0.0001544579,0.0001047257,0.0003992424,0.0001370624],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001997387,"about_ca_system_score_gemma":0.0001459952,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001803844,"about_ca_topic_score_gemma":0.0005117708,"domain_scores_codex":[0.9999293,0.00001628704,0.000008364475,0.0000097246,0.00001825555,0.00001806928],"domain_scores_gemma":[0.9999423,0.00001635536,0.0000151014,0.000006179255,0.000004748275,0.00001527412],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003000266,0.00007771044,0.0001117704,0.00004202471,0.000003593383,0.0000370076,0.000004856967,0.0000656355,0.9961752,0.0000579878,0.00003780596,0.003086548],"study_design_scores_gemma":[0.00005185109,0.0008115487,0.001906016,0.000005461673,0.00001000318,0.0001661091,0.000007299847,0.0003753388,0.9956727,0.00002551296,0.0009651936,0.000003016162],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99128,0.003481613,0.002428317,0.0002140656,0.00006405349,0.00006763629,0.0001560213,0.00009735651,0.002210862],"genre_scores_gemma":[0.9941493,0.001897977,0.002572817,0.00005774891,0.0000194627,0.00003560706,0.00020717,0.0000070793,0.001052898],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008248448,"threshold_uncertainty_score":0.002759337,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0150920346559443,"score_gpt":0.2457420483091084,"score_spread":0.2306500136531641,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}