{"id":"W2103634797","doi":"10.1128/aac.47.8.2545-2550.2003","title":"Subinhibitory Concentrations of the Deformylase Inhibitor Actinonin Increase Bacterial Release of Neutrophil-Activating Peptides: a New Approach to Antimicrobial Chemotherapy","year":2003,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children’s Health Research Institute","funders":"Medical Research Council; Stiftelsen för Strategisk Forskning","keywords":"Innate immune system; Antimicrobial peptides; Antimicrobial; Biochemistry; Biology; Peptide; Secretion; Microbiology; Escherichia coli; Receptor; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001788847,0.0003161703,0.0005895653,0.0001421074,0.0001796737,0.0000416874,0.0001340506,0.0001961667,0.0002912088],"category_scores_gemma":[0.00007704725,0.0002435534,0.0003401456,0.0005010187,0.000216003,0.0001387139,0.00003535017,0.0002637007,0.00000525935],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006179418,"about_ca_system_score_gemma":0.0003609477,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002645773,"about_ca_topic_score_gemma":0.000008753683,"domain_scores_codex":[0.9982341,0.0001074872,0.0006428791,0.0004294685,0.0002462287,0.0003398351],"domain_scores_gemma":[0.9987507,0.00003474889,0.0003735096,0.0004101629,0.0001475985,0.0002832057],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007429585,0.0009230484,0.004498593,0.0001387651,0.0001630806,0.000002916554,0.0009718606,0.00002056261,0.964779,0.00009839525,0.02662629,0.0010346],"study_design_scores_gemma":[0.006174979,0.000134726,0.006210824,0.0005573052,0.00008753741,0.00007258881,0.0001976332,0.00005062938,0.9766735,0.000009530375,0.009555908,0.000274869],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956536,0.000005867128,0.0002757816,0.001984861,0.00008850593,0.0006545755,0.00006216042,0.00002823841,0.001246376],"genre_scores_gemma":[0.9891952,0.00009710535,0.002346755,0.007259107,0.0002846761,0.000004797185,0.00004844883,0.00004896662,0.0007149384],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01707038,"threshold_uncertainty_score":0.9931817,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0150920346559443,"score_gpt":0.2457420483091084,"score_spread":0.2306500136531641,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}