{"id":"W2103693185","doi":"10.1177/1087057114525852","title":"Identification of Potent and Selective Inhibitors of the Plasmodium falciparum M18 Aspartyl Aminopeptidase (PfM18AAP) of Human Malaria via High-Throughput Screening","year":2014,"lang":"en","type":"article","venue":"SLAS DISCOVERY","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Human Genome Research Institute; National Institute of Mental Health; National Institute for Health and Care Research; Canadian Institutes of Health Research; Health Canada; National Institutes of Health; National Health Research Institutes","keywords":"Plasmodium falciparum; High-throughput screening; Exopeptidase; Biochemistry; Enzyme; Biology; Recombinant DNA; Chemistry; Molecular biology; Malaria; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004428213,0.0007963148,0.0009291083,0.0006014523,0.0002503094,0.0004286665,0.0004153505,0.000312747,0.001351503],"category_scores_gemma":[0.000285528,0.0002916772,0.0003383394,0.0005996159,0.0001411458,0.000241811,0.0002820198,0.0006357667,0.0005123114],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005012022,"about_ca_system_score_gemma":0.0004354601,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006065776,"about_ca_topic_score_gemma":0.002276956,"domain_scores_codex":[0.9997482,0.00004444701,0.00001971723,0.00003760589,0.0001073931,0.00004268346],"domain_scores_gemma":[0.9998932,0.00002960717,0.00002079258,0.000008105024,0.00002832182,0.00002000089],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000509428,0.0006033089,0.0009698618,0.0004388301,0.00008740326,0.0002749598,0.00005327925,0.001831546,0.9616159,0.0002489569,0.001663227,0.03170338],"study_design_scores_gemma":[0.0005086564,0.004665157,0.00739356,0.00004318673,0.0003100958,0.001676909,0.00005784278,0.006375766,0.9587988,0.0001297398,0.02000171,0.00003856336],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9319773,0.02690227,0.02519988,0.0006379114,0.0001045297,0.001946243,0.005497683,0.0008826631,0.006851418],"genre_scores_gemma":[0.9494379,0.01795775,0.01857863,0.0002572082,0.00004754145,0.0008924149,0.006600855,0.00005373903,0.006173981],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001351503,"threshold_uncertainty_score":0.004521251,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01041042325033952,"score_gpt":0.2484621411932532,"score_spread":0.2380517179429137,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}