{"id":"W2103703726","doi":"10.1038/ng1131","title":"Loss of neuropathy target esterase in mice links organophosphate exposure to hyperactivity","year":2003,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Pesticide Exposure and Toxicity","field":"Agricultural and Biological Sciences","cited_by":176,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Canadian Institutes of Health Research; National Institutes of Health; U.S. Department of Defense","keywords":"Organophosphate; Biology; Carboxylesterase; Esterase; Auditory neuropathy; Genetics; Toxicology; Enzyme; Hearing loss; Biochemistry; Pesticide; Audiology; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002056832,0.0001504585,0.0002089526,0.00001800811,0.00004602474,0.00001935497,0.0002112518,0.0003970591,0.00009947292],"category_scores_gemma":[0.0003477138,0.00006893487,0.00005202775,0.0005176607,0.00002595285,0.00004557758,0.00004620723,0.0005792711,0.00001612131],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000142435,"about_ca_system_score_gemma":0.00001540943,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002163502,"about_ca_topic_score_gemma":0.000278657,"domain_scores_codex":[0.9988888,0.0001241296,0.0002288962,0.0002931521,0.0002038049,0.0002612066],"domain_scores_gemma":[0.9994547,0.0001482901,0.00009799069,0.00008394547,0.00009484433,0.0001202766],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00004097858,0.0002140033,0.4478319,0.000008334386,0.000005282316,0.00006605697,0.00007532611,0.0001958079,0.5463357,0.00004759689,0.0001290742,0.005049928],"study_design_scores_gemma":[0.0001490587,0.0003137452,0.7096281,0.00001202635,0.000006384208,0.00001213146,0.000023463,0.000009096132,0.2803206,0.0002776415,0.009080589,0.0001671921],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976913,0.001068911,0.000007282373,0.0003493231,0.0002906883,0.0001671916,0.00004284403,0.00001790794,0.000364606],"genre_scores_gemma":[0.9974412,0.00004358278,0.001136334,0.001198446,0.0001056039,0.000003857035,0.000008883612,0.000001795605,0.00006024338],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2660151,"threshold_uncertainty_score":0.3062483,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008958577636142284,"score_gpt":0.2217934303073872,"score_spread":0.2128348526712449,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}