{"id":"W2103705477","doi":"10.1089/10430340050083298","title":"Enhanced Ganciclovir Killing and Bystander Effect of Human Tumor Cells Transduced with a Retroviral Vector Carrying a Herpes Simplex Virus Thymidine Kinase Gene Mutant","year":2000,"lang":"en","type":"article","venue":"Human Gene Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Hôtel-Dieu de Québec; Centre hospitalier universitaire de Québec","funders":"Medical Research Council","keywords":"Suicide gene; Bystander effect; Thymidine kinase; Ganciclovir; Genetic enhancement; Biology; Herpes simplex virus; Transfection; Transduction (biophysics); Mutant; Cancer research; Virology; Viral vector; Cell culture; Molecular biology; Gene; Virus; Immunology; Human cytomegalovirus; Genetics; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005065032,0.0005067881,0.000588831,0.0001136378,0.0003271922,0.0000530014,0.0003371063,0.0001555492,0.0004143136],"category_scores_gemma":[0.000004522304,0.0004115969,0.000178264,0.0002078724,0.0002789794,0.00001286437,0.00003113921,0.0001840972,0.000004543143],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004408537,"about_ca_system_score_gemma":0.00008653434,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001132603,"about_ca_topic_score_gemma":0.0002337942,"domain_scores_codex":[0.9973689,0.000361343,0.0004375765,0.0007800914,0.0003990653,0.0006529905],"domain_scores_gemma":[0.998833,0.00003155519,0.0001456349,0.0006997677,0.00009651554,0.0001935287],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.009618713,0.0001368454,0.00005452567,0.00005845054,0.0002517106,0.00003709399,0.0004502725,0.0001303821,0.973819,0.000001860907,0.00001187672,0.01542932],"study_design_scores_gemma":[0.005560278,0.01729673,0.0002553062,0.00003952066,0.00003616388,0.000018866,0.00003124349,0.00003269602,0.9758816,0.0000166698,0.0003568475,0.0004740143],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955936,0.003160148,0.0001376717,0.00001803328,0.0000282529,0.00085597,0.00007560135,0.0000425728,0.00008814511],"genre_scores_gemma":[0.997927,0.001045453,0.00009592314,0.00015242,0.000268019,0.00009292737,0.0001138235,0.0001328487,0.0001716118],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01715989,"threshold_uncertainty_score":0.9998336,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01357784083355221,"score_gpt":0.2807881129472474,"score_spread":0.2672102721136952,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}