{"id":"W2103705477","doi":"10.1089/10430340050083298","title":"Enhanced Ganciclovir Killing and Bystander Effect of Human Tumor Cells Transduced with a Retroviral Vector Carrying a Herpes Simplex Virus Thymidine Kinase Gene Mutant","year":2000,"lang":"en","type":"article","venue":"Human Gene Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Hôtel-Dieu de Québec; Centre hospitalier universitaire de Québec","funders":"Medical Research Council","keywords":"Suicide gene; Bystander effect; Thymidine kinase; Ganciclovir; Genetic enhancement; Biology; Herpes simplex virus; Transfection; Transduction (biophysics); Mutant; Cancer research; Virology; Viral vector; Cell culture; Molecular biology; Gene; Virus; Immunology; Human cytomegalovirus; Genetics; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003072989,0.0004349047,0.0003983279,0.0003008234,0.0001105622,0.0003019667,0.0001569611,0.0002972145,0.001049697],"category_scores_gemma":[0.0001758576,0.0001032114,0.0002247054,0.0002045865,0.0002042705,0.0001719799,0.0001514748,0.0004372329,0.0002303637],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000249368,"about_ca_system_score_gemma":0.000221705,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001019755,"about_ca_topic_score_gemma":0.0006617372,"domain_scores_codex":[0.9997733,0.00005873715,0.00002150513,0.00004100573,0.00006304659,0.000042478],"domain_scores_gemma":[0.9998741,0.00005281507,0.00001660186,0.00002340186,0.00001123523,0.00002182616],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009521712,0.00004626235,0.0001162983,0.00002461558,0.000007012676,0.00003504961,0.000025479,0.00007292819,0.9976358,0.00011655,0.00002650767,0.001798143],"study_design_scores_gemma":[0.00001847461,0.0003316437,0.0007278146,0.000002038717,0.000008897789,0.0001540025,0.00000513504,0.0005066976,0.9976621,0.00002374842,0.0005571645,0.000002306398],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992908,0.001948857,0.003460608,0.00004072283,0.00002517974,0.00004390298,0.0001740017,0.0000773689,0.001321342],"genre_scores_gemma":[0.9939939,0.0008347973,0.003036101,0.00001759111,0.000007379352,0.00002349128,0.0003578138,0.000024797,0.00170413],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001049697,"threshold_uncertainty_score":0.003511608,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01357784083355221,"score_gpt":0.2807881129472474,"score_spread":0.2672102721136952,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}