{"id":"W2103743913","doi":"10.1158/1541-7786.mcr-06-0182","title":"Genetic and Expression Aberrations of E3 Ubiquitin Ligases in Human Breast Cancer","year":2006,"lang":"en","type":"review","venue":"Molecular Cancer Research","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women's College Hospital; Sunnybrook Health Science Centre","funders":"National Institute of General Medical Sciences","keywords":"Breast cancer; Cancer research; Carcinogenesis; Biology; Cancer; Ubiquitin ligase; DNA methylation; Ubiquitin; Gene; Gene expression; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003642906,0.0006938051,0.001151324,0.001949684,0.000215671,0.0005337925,0.0005410686,0.0007848817,0.002326519],"category_scores_gemma":[0.0003335254,0.0002047479,0.0002971675,0.002647052,0.0002676354,0.0006548208,0.0003884305,0.0006241552,0.003388841],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005862645,"about_ca_system_score_gemma":0.0005134548,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001110186,"about_ca_topic_score_gemma":0.001493186,"domain_scores_codex":[0.9998301,0.00002419676,0.00002134148,0.00003679319,0.0000699185,0.00001758125],"domain_scores_gemma":[0.9998842,0.00003066087,0.00002354775,0.000005423979,0.00004231684,0.00001374744],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009979642,0.00004533975,0.0006543567,0.005364982,0.00007170532,0.0006048881,0.0000506174,0.0002966844,0.006480056,0.001295218,0.01593594,0.9691004],"study_design_scores_gemma":[0.00001774331,0.0001291512,0.003675372,0.001256657,0.0001464117,0.007770051,0.00009437542,0.0001064091,0.004125799,0.001756601,0.9809002,0.00002126855],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004445589,0.9975716,0.0003072057,0.0001397846,0.00006461878,0.000004158895,0.00002811089,0.0000155902,0.00142426],"genre_scores_gemma":[0.001727091,0.9963226,0.000390883,0.0001123384,0.00004601589,0.000004971859,0.00004851818,0.000001777404,0.001345739],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002326519,"threshold_uncertainty_score":0.007782996,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07306274648779967,"score_gpt":0.420005849616394,"score_spread":0.3469431031285943,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}