{"id":"W2103743913","doi":"10.1158/1541-7786.mcr-06-0182","title":"Genetic and Expression Aberrations of E3 Ubiquitin Ligases in Human Breast Cancer","year":2006,"lang":"en","type":"review","venue":"Molecular Cancer Research","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women's College Hospital; Sunnybrook Health Science Centre","funders":"National Institute of General Medical Sciences","keywords":"Breast cancer; Cancer research; Carcinogenesis; Biology; Cancer; Ubiquitin ligase; DNA methylation; Ubiquitin; Gene; Gene expression; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000460632,0.0003386955,0.0007230812,0.0003534312,0.0001321711,0.00004852659,0.0004073457,0.00044826,0.000105902],"category_scores_gemma":[0.0000373263,0.0003110588,0.0002001228,0.0004254503,0.0002787098,0.000004199599,0.0004119507,0.0005026612,0.000002599834],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000895527,"about_ca_system_score_gemma":0.0007027942,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001869028,"about_ca_topic_score_gemma":0.0007699892,"domain_scores_codex":[0.9971079,0.00060699,0.000557746,0.0007297489,0.0004555923,0.0005420238],"domain_scores_gemma":[0.9988794,0.00002929268,0.0001832397,0.0005626084,0.0002183716,0.0001270499],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000378817,0.0001952499,0.0003323282,0.01193485,0.0001253766,0.00007630707,0.00007516812,0.00003443504,0.5582298,0.00008377114,0.002770862,0.426104],"study_design_scores_gemma":[0.0006956675,0.0002412669,0.000422969,0.01397745,0.0001410389,0.00006071048,0.00002623912,0.000006847989,0.2634217,0.0001517585,0.7200814,0.0007729071],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.03470841,0.9630326,0.0000232377,0.00003899327,0.00003999986,0.001004038,0.0005520532,0.000007131955,0.0005935485],"genre_scores_gemma":[0.0216093,0.9756961,0.00009164258,0.00002016472,0.000260883,0.001520807,0.0002356117,0.00008709716,0.000478374],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.7173105,"threshold_uncertainty_score":0.9999341,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07306274648779967,"score_gpt":0.420005849616394,"score_spread":0.3469431031285943,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}