{"id":"W2103759210","doi":"10.1002/emmm.201100604","title":"Genetic partitioning of interleukin‐6 signalling in mice dissociates Stat3 from Smad3‐mediated lung fibrosis","year":2012,"lang":"en","type":"article","venue":"EMBO Molecular Medicine","topic":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","field":"Medicine","cited_by":154,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; BC Research (Canada)","funders":"National Health and Medical Research Council; Canadian Institutes of Health Research; Medical Research Council; State Government of Victoria","keywords":"Fibrosis; Bleomycin; Pulmonary fibrosis; Idiopathic pulmonary fibrosis; STAT3; Cancer research; Immunology; Glycoprotein 130; Inflammation; Lung; Medicine; Biology; Pathology; Signal transduction; Interleukin 6; Internal medicine; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002744397,0.000252501,0.0006342113,0.0002065283,0.00004337179,0.000007627771,0.0001276033,0.0001347685,0.0008257075],"category_scores_gemma":[0.0004269091,0.0002012575,0.0001456895,0.0003757441,0.0001593127,0.000113678,0.00006035116,0.0002572045,0.00001690282],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001546421,"about_ca_system_score_gemma":0.00008803625,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001065068,"about_ca_topic_score_gemma":0.00002505548,"domain_scores_codex":[0.9979279,0.0001287299,0.0006931993,0.0002932517,0.0004588381,0.0004981064],"domain_scores_gemma":[0.9988944,0.000225725,0.0002070444,0.0002296717,0.0001125224,0.0003306525],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.003112437,0.0005591417,0.1129665,0.0005590597,0.0003230907,0.0004399363,0.004419787,0.00006672532,0.8757589,0.0001303107,0.00084136,0.000822839],"study_design_scores_gemma":[0.01553823,0.009646493,0.784658,0.02624289,0.003818794,0.0001606166,0.009053679,0.01521768,0.1307774,0.0009487904,0.00214794,0.001789462],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9838802,0.0115934,0.002335937,0.0005775986,0.0003093678,0.0003548551,0.00006815107,0.00004747649,0.0008330808],"genre_scores_gemma":[0.9971815,0.000233059,0.001050334,0.0006337228,0.0004404301,0.00003348635,0.000313383,0.0000468811,0.00006717363],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7449814,"threshold_uncertainty_score":0.9040918,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008726679027266577,"score_gpt":0.2551593103376393,"score_spread":0.2464326313103728,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}