{"id":"W2103783819","doi":"10.2337/diabetes.50.6.1464","title":"The Antihyperglycemic Drug α-Lipoic Acid Stimulates Glucose Uptake via Both GLUT4 Translocation and GLUT4 Activation","year":2001,"lang":"en","type":"article","venue":"Diabetes","topic":"Biochemical Acid Research Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":215,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"Novo Nordisk Canada; Medical Research Council Canada; Medical Research Council; Novo Nordisk; University of Toronto; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Canadian Diabetes Association; National Science Foundation","keywords":"GLUT4; Glucose uptake; Glucose transporter; Wortmannin; Alpha-Lipoic Acid; Biology; Lipoic acid; MAPK/ERK pathway; Endocrinology; Internal medicine; Kinase; Insulin; Biochemistry; Chemistry; Phosphatidylinositol; Medicine; Antioxidant","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008205771,0.0004030821,0.0002009153,0.0002283024,0.0001051851,0.0001818313,0.00009699361,0.0001608877,0.001868016],"category_scores_gemma":[0.00006586276,0.0001325516,0.0001764888,0.0001822731,0.0001259413,0.0001467731,0.0001192473,0.0004821831,0.0003071674],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002141943,"about_ca_system_score_gemma":0.0001088517,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004212283,"about_ca_topic_score_gemma":0.0008425552,"domain_scores_codex":[0.9999453,0.00001008895,0.00000527674,0.00001178652,0.00001516398,0.00001245557],"domain_scores_gemma":[0.9999497,0.00000630435,0.00002147376,0.000002980317,0.000005597876,0.0000140123],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006988632,0.00009272062,0.0003173815,0.00009725492,0.00001541163,0.00005716848,0.000007746104,0.00003549875,0.9936579,0.00006802432,0.0001184345,0.004833612],"study_design_scores_gemma":[0.0001530967,0.001848753,0.01212913,0.00002328824,0.00006123247,0.0003953279,0.00003423313,0.0004195035,0.9766716,0.00008596126,0.00817016,0.000007748416],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.974258,0.0168684,0.003228245,0.0003792335,0.000170937,0.00004708966,0.0006896229,0.0001346079,0.004223822],"genre_scores_gemma":[0.9749502,0.01372842,0.004397048,0.0002568639,0.00009432379,0.00004638653,0.001095323,0.00002540308,0.005405998],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001868016,"threshold_uncertainty_score":0.00624913,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00720505492846589,"score_gpt":0.2377729828889061,"score_spread":0.2305679279604402,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}