{"id":"W2103783819","doi":"10.2337/diabetes.50.6.1464","title":"The Antihyperglycemic Drug α-Lipoic Acid Stimulates Glucose Uptake via Both GLUT4 Translocation and GLUT4 Activation","year":2001,"lang":"en","type":"article","venue":"Diabetes","topic":"Biochemical Acid Research Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":215,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"Novo Nordisk Canada; Medical Research Council Canada; Medical Research Council; Novo Nordisk; University of Toronto; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Canadian Diabetes Association; National Science Foundation","keywords":"GLUT4; Glucose uptake; Glucose transporter; Wortmannin; Alpha-Lipoic Acid; Biology; Lipoic acid; MAPK/ERK pathway; Endocrinology; Internal medicine; Kinase; Insulin; Biochemistry; Chemistry; Phosphatidylinositol; Medicine; Antioxidant","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002152209,0.0001778263,0.0001386764,0.00002951924,0.0003001048,0.00005929885,0.0001893021,0.0001117173,0.000006113972],"category_scores_gemma":[0.0001801598,0.0001266614,0.00005898889,0.0001425869,0.0002497339,0.00001149181,0.00009901565,0.000128035,0.000006935252],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001574894,"about_ca_system_score_gemma":0.00002445726,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001268751,"about_ca_topic_score_gemma":0.00001200121,"domain_scores_codex":[0.9988644,0.00005548093,0.0001868268,0.0003363128,0.000173044,0.0003839352],"domain_scores_gemma":[0.9994308,0.00006730606,0.00005528811,0.0002706334,0.00009391135,0.000082013],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009160882,0.0000373774,0.004659838,0.0000174501,0.00007232497,3.316269e-7,0.00004996283,0.000005966994,0.9548902,0.00001158539,0.0004910988,0.03967227],"study_design_scores_gemma":[0.0004733029,0.0001375889,0.00733858,0.00002268194,0.0000132704,0.000001484638,0.00006088942,0.0004536491,0.980207,0.0002750124,0.01084619,0.0001703158],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9849516,0.01319887,0.0002208288,0.001191498,0.00006394464,0.0002210096,0.000007457609,0.00002560469,0.0001192521],"genre_scores_gemma":[0.992977,0.006209917,0.0001435124,0.000163588,0.0001877076,0.00004595313,0.00008533489,0.00002081491,0.000166222],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03950195,"threshold_uncertainty_score":0.51651,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00720505492846589,"score_gpt":0.2377729828889061,"score_spread":0.2305679279604402,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}