{"id":"W2103796833","doi":"10.1152/ajprenal.00598.2012","title":"Acidosis-mediated regulation of the NHE1 isoform of the Na<sup>+</sup>/H<sup>+</sup>exchanger in renal cells","year":2013,"lang":"en","type":"article","venue":"American Journal of Physiology-Renal Physiology","topic":"Ion Transport and Channel Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Intracellular pH; Sodium–hydrogen antiporter; Gene isoform; Acidosis; Cytosol; Extracellular; Intracellular; MAPK/ERK pathway; Molecular biology; Chemistry; Phosphorylation; Cell biology; Biology; Biochemistry; Sodium; Endocrinology; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002924096,0.000324506,0.0007368021,0.0001529899,0.00009490097,0.000005651904,0.0007152654,0.0002557912,0.0001532682],"category_scores_gemma":[0.0000681012,0.0001994866,0.0005182427,0.0005183621,0.001220176,0.0000322229,0.0001456452,0.0004028011,0.00000839747],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003966385,"about_ca_system_score_gemma":0.0001842476,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001476539,"about_ca_topic_score_gemma":0.00001229354,"domain_scores_codex":[0.9974449,0.0004596006,0.0009925474,0.0003581571,0.0002908826,0.0004539545],"domain_scores_gemma":[0.9973688,0.00009182082,0.001431245,0.0005620989,0.0004532314,0.00009279621],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004987505,0.0001609199,0.0008050502,0.0000307008,0.000153956,2.861891e-7,0.0004697037,0.03172335,0.963926,0.00002364491,0.0007604992,0.00144719],"study_design_scores_gemma":[0.001302848,0.001381704,0.3329693,0.0001257852,0.00008165155,0.00001896188,0.0007225912,0.003123251,0.6582505,0.001048181,0.000692878,0.0002823627],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987592,0.0001482766,0.00006572148,0.0004591896,0.000183009,0.0003007118,0.00003535952,0.00000470754,0.00004388762],"genre_scores_gemma":[0.998642,0.0001292227,0.0001453801,0.0004029099,0.0004515742,0.00001872733,0.00007577732,0.00003151778,0.0001028808],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3321643,"threshold_uncertainty_score":0.8134829,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005161944513470651,"score_gpt":0.201505414478873,"score_spread":0.1963434699654024,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}