{"id":"W2103802459","doi":"10.1161/jaha.112.000901","title":"Histone Deacetylase Activity Selectively Regulates Notch‐Mediated Smooth Muscle Differentiation in Human Vascular Cells","year":2012,"lang":"en","type":"article","venue":"Journal of the American Heart Association","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Micromolding Solutions (Canada)","funders":"National Center for Research Resources; National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute","keywords":"Notch signaling pathway; Cell biology; Hes3 signaling axis; Protein kinase B; PI3K/AKT/mTOR pathway; Signal transduction; Histone deacetylase; Myosin light-chain kinase; Rho-associated protein kinase; Biology; Cancer research; Histone; Myosin; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001535886,0.0001694526,0.0001935273,0.0001455218,0.0001102273,0.0002322794,0.0001457644,0.0001323615,0.001124531],"category_scores_gemma":[0.00008097242,0.0001127753,0.0002288006,0.0001696181,0.0001325322,0.00007843355,0.0001153949,0.0002006675,0.0002819397],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003275977,"about_ca_system_score_gemma":0.000202505,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001065383,"about_ca_topic_score_gemma":0.001689784,"domain_scores_codex":[0.9998994,0.00001290689,0.00001072812,0.00002851447,0.00002397937,0.00002453737],"domain_scores_gemma":[0.999962,0.000006018022,0.000009633624,0.000005130784,0.000007586453,0.000009568278],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001553554,0.00002414206,0.0004108161,0.00003929612,0.000009452264,0.00002900798,0.00001076285,0.00003370943,0.9970514,0.00006967845,0.00005012895,0.002116138],"study_design_scores_gemma":[0.00003298456,0.0002807677,0.007631336,0.000004705136,0.00004209746,0.000180333,0.00001738952,0.000700842,0.9875877,0.00002650775,0.003492065,0.000003189294],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9886559,0.00589336,0.00270482,0.00006188035,0.00004465103,0.0000372301,0.0004281802,0.00005279709,0.002121204],"genre_scores_gemma":[0.9939301,0.00189554,0.001464551,0.00003866587,0.00001341581,0.00003116198,0.000722073,0.000008276065,0.001896269],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001124531,"threshold_uncertainty_score":0.003761947,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008712103900291214,"score_gpt":0.2806062154099523,"score_spread":0.2718941115096611,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}