{"id":"W2103849632","doi":"10.1371/journal.pone.0135106","title":"Parasporin-2 from a New Bacillus thuringiensis 4R2 Strain Induces Caspases Activation and Apoptosis in Human Cancer Cells","year":2015,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Insect Resistance and Genetics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"Agriculture and Agri-Food Canada; Université du Québec à Trois-Rivières","funders":"Canadian Institutes of Health Research; Canada Research Chairs; Université du Québec à Trois-Rivières","keywords":"XIAP; Apoptosis; Cytotoxic T cell; Propidium iodide; Caspase; Molecular biology; Biology; Protein kinase B; Annexin; Cancer cell; Programmed cell death; Poly ADP ribose polymerase; Inhibitor of apoptosis; Bacillus thuringiensis; Cancer research; Flow cytometry; Cancer; Biochemistry; In vitro; Polymerase; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001286549,0.0004294149,0.0002400198,0.0002611291,0.0001339433,0.000161562,0.0001356706,0.0002066533,0.0007063864],"category_scores_gemma":[0.0001031423,0.0001135819,0.0003106505,0.0002038983,0.0001127619,0.000108801,0.0001437706,0.0004917069,0.0002812607],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001988205,"about_ca_system_score_gemma":0.0001667499,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000490178,"about_ca_topic_score_gemma":0.0006870928,"domain_scores_codex":[0.9998916,0.00002001653,0.0000141445,0.00002249883,0.00003219906,0.0000195245],"domain_scores_gemma":[0.9999349,0.00000860051,0.00002326686,0.0000111455,0.000007538921,0.00001460318],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00010825,0.00001982239,0.0001429636,0.00003544851,0.000006811768,0.00007415881,0.000009225495,0.00001705244,0.998872,0.00001475961,0.00003233301,0.0006672107],"study_design_scores_gemma":[0.00004556692,0.001195249,0.009077513,0.000008430761,0.00003698359,0.001325383,0.00003701859,0.0003265794,0.9844466,0.00002914356,0.003465863,0.000005847],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948049,0.002146538,0.001352376,0.0001332679,0.00003525027,0.00006592197,0.0006005597,0.00006203609,0.000799191],"genre_scores_gemma":[0.9907668,0.001715468,0.002637172,0.00006686501,0.00002210998,0.00007462811,0.002523761,0.00001720726,0.002176183],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007063864,"threshold_uncertainty_score":0.002363086,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05877379356628225,"score_gpt":0.2601545704404312,"score_spread":0.2013807768741489,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}