{"id":"W2103849632","doi":"10.1371/journal.pone.0135106","title":"Parasporin-2 from a New Bacillus thuringiensis 4R2 Strain Induces Caspases Activation and Apoptosis in Human Cancer Cells","year":2015,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Insect Resistance and Genetics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"Agriculture and Agri-Food Canada; Université du Québec à Trois-Rivières","funders":"Canadian Institutes of Health Research; Canada Research Chairs; Université du Québec à Trois-Rivières","keywords":"XIAP; Apoptosis; Cytotoxic T cell; Propidium iodide; Caspase; Molecular biology; Biology; Protein kinase B; Annexin; Cancer cell; Programmed cell death; Poly ADP ribose polymerase; Inhibitor of apoptosis; Bacillus thuringiensis; Cancer research; Flow cytometry; Cancer; Biochemistry; In vitro; Polymerase; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005357332,0.0001187109,0.0001435042,0.00003912637,0.00003618855,0.00002275634,0.00007659286,0.0001200566,0.00001775942],"category_scores_gemma":[0.00002656795,0.000122117,0.00001959498,0.00006755524,0.00003225409,0.000005615947,0.00004484355,0.00007097839,0.000002179671],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002667337,"about_ca_system_score_gemma":0.00009547414,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002302604,"about_ca_topic_score_gemma":0.00192631,"domain_scores_codex":[0.9992631,0.00002605761,0.000136164,0.0002590729,0.0001430248,0.0001725844],"domain_scores_gemma":[0.9996085,0.000008122512,0.00005761251,0.0001746743,0.00005377688,0.00009731693],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004795839,0.0001469808,0.004428869,0.00001371568,0.00007895903,0.000001183277,0.0003711047,0.0000334891,0.993719,0.000003891462,0.0002248917,0.0009299563],"study_design_scores_gemma":[0.0005243379,0.0001297553,0.01103556,0.00006113373,0.00003771242,1.336791e-7,0.000165976,0.000007273392,0.9875243,0.0001840761,0.0001727603,0.0001569826],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985777,0.0008745557,0.00002180245,0.0001178265,0.0000267672,0.0001295968,0.00005223613,0.000007697995,0.0001917893],"genre_scores_gemma":[0.9980316,0.0003382156,0.0007054033,0.0001273243,0.0002724672,0.0000186521,0.00008873617,0.00001452904,0.0004031135],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006606695,"threshold_uncertainty_score":0.4979786,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05877379356628225,"score_gpt":0.2601545704404312,"score_spread":0.2013807768741489,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}