{"id":"W2103907859","doi":"10.1186/ar2925","title":"Local leptin production in osteoarthritis subchondral osteoblasts may be responsible for their abnormal phenotypic expression","year":2010,"lang":"en","type":"article","venue":"Arthritis Research & Therapy","topic":"Regulation of Appetite and Obesity","field":"Neuroscience","cited_by":115,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal; Hôpital Maisonneuve-Rosemont; Hôpital Notre-Dame","funders":"Canadian Institutes of Health Research; Arthritis Society","keywords":"Rheumatology; Phenotype; Osteoarthritis; Subchondral bone; Medicine; Leptin; Internal medicine; Adipokine; Pathology; Biology; Obesity; Genetics; Gene; Articular cartilage","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002096864,0.000236758,0.0002727624,0.0004824271,0.0006717195,0.0002012255,0.0004836397,0.0002100014,0.0004290142],"category_scores_gemma":[0.0008430023,0.0002160356,0.000116959,0.0007724977,0.0007330951,0.0008426971,0.0001245473,0.0009001667,0.00009691733],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005468055,"about_ca_system_score_gemma":0.0002435458,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006045021,"about_ca_topic_score_gemma":0.002133183,"domain_scores_codex":[0.9961401,0.0007793283,0.0004171884,0.0008699592,0.0008325719,0.0009608562],"domain_scores_gemma":[0.99805,0.000747814,0.00008023995,0.0006613549,0.0002528824,0.0002077308],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001390158,0.0001651925,0.0006681154,0.000007822677,9.539856e-7,0.00001761696,0.000682667,0.00003126275,0.7953326,0.0009914113,0.001610859,0.1991014],"study_design_scores_gemma":[0.002463582,0.0008571951,0.003952957,0.0001027473,2.795508e-7,0.00004351186,0.0002400928,0.0001133755,0.9042204,0.003201991,0.0845855,0.0002184002],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917358,0.000283494,0.0001511131,0.004663721,0.0005812255,0.001612042,0.00003751863,0.0001018141,0.0008332739],"genre_scores_gemma":[0.9953561,0.001358203,0.0006807563,0.0002363564,0.0003991869,0.0003496185,0.00001812159,0.00005181062,0.001549855],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.198883,"threshold_uncertainty_score":0.8809674,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05334669218422056,"score_gpt":0.3313523019975954,"score_spread":0.2780056098133749,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}