{"id":"W2103933819","doi":"10.1124/dmd.32.4.460","title":"THE EFFECT OF CIMETIDINE ON DEXTROMETHORPHAN O-DEMETHYLASE ACTIVITY OF HUMAN LIVER MICROSOMES AND RECOMBINANT CYP2D6","year":2004,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":46,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Cimetidine; Dextromethorphan; Quinidine; Microsome; CYP2D6; Chemistry; Recombinant DNA; Pharmacology; Microsoma; Cytochrome P450; Drug interaction; Pharmacokinetics; Enzyme; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009961914,0.0007274,0.0008661072,0.0003796034,0.0003367603,0.0005613196,0.0005377652,0.0008956182,0.002253796],"category_scores_gemma":[0.002737443,0.0005836536,0.0008692141,0.0005335685,0.0006860347,0.0006514725,0.0003144215,0.001101963,0.000693246],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008106886,"about_ca_system_score_gemma":0.0007000336,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004686671,"about_ca_topic_score_gemma":0.004358567,"domain_scores_codex":[0.9989901,0.0004925968,0.00009901594,0.0001338603,0.0001283929,0.0001560602],"domain_scores_gemma":[0.9982089,0.00111953,0.0001340515,0.0002087979,0.0001577369,0.0001708696],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.02218195,0.0006190353,0.002369119,0.0003167774,0.0002102637,0.0003352214,0.000259597,0.000969337,0.9619492,0.0005060259,0.0005061403,0.009777268],"study_design_scores_gemma":[0.0002290626,0.002900585,0.006974113,0.00001123,0.00009344515,0.0003088813,0.00005160546,0.002245348,0.9859824,0.00004034494,0.00114605,0.00001698565],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920489,0.003563754,0.00100528,0.0002738236,0.0001869742,0.0000454329,0.0005626795,0.00008985143,0.002223348],"genre_scores_gemma":[0.9933187,0.001244856,0.001197236,0.00006745788,0.00008353149,0.00002897196,0.001497634,0.00002998957,0.002531735],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004686671,"threshold_uncertainty_score":0.009318829,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02910905688775452,"score_gpt":0.3750711169909364,"score_spread":0.3459620601031819,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}