{"id":"W2103933819","doi":"10.1124/dmd.32.4.460","title":"THE EFFECT OF CIMETIDINE ON DEXTROMETHORPHAN O-DEMETHYLASE ACTIVITY OF HUMAN LIVER MICROSOMES AND RECOMBINANT CYP2D6","year":2004,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":46,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Cimetidine; Dextromethorphan; Quinidine; Microsome; CYP2D6; Chemistry; Recombinant DNA; Pharmacology; Microsoma; Cytochrome P450; Drug interaction; Pharmacokinetics; Enzyme; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001583171,0.0002788454,0.0005203217,0.0001565009,0.0004669262,0.00002239219,0.0001616566,0.0001542555,0.00003020578],"category_scores_gemma":[0.00007170622,0.0001941839,0.0001333045,0.0002044318,0.0004957304,0.000115926,0.0001051822,0.0003774021,0.000004067206],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001439134,"about_ca_system_score_gemma":0.00002253217,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001182251,"about_ca_topic_score_gemma":0.00001063863,"domain_scores_codex":[0.9978948,0.0009134404,0.0003653132,0.0003234434,0.0001878765,0.0003150822],"domain_scores_gemma":[0.9985625,0.0006754965,0.0002887254,0.0002090618,0.00007282983,0.0001913487],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001112847,0.0002684405,0.0009565544,0.0001290568,0.0001642352,0.000007378551,0.0005529266,0.00004090244,0.9098636,0.006022043,0.00007461456,0.08080743],"study_design_scores_gemma":[0.004109198,0.0003343345,0.03345118,0.0000299174,0.0006074905,0.00001121314,0.00003111334,0.00007771908,0.9557105,0.001847004,0.003596186,0.0001941543],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.982559,0.01556547,0.00005174891,0.0002789964,0.000635046,0.0004933419,0.0001060933,0.00001952642,0.0002908186],"genre_scores_gemma":[0.9926553,0.00684124,0.0001019234,0.0001175927,0.0001197789,0.00003922343,0.00001698486,0.00002133935,0.00008659569],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08061328,"threshold_uncertainty_score":0.7918591,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02910905688775452,"score_gpt":0.3750711169909364,"score_spread":0.3459620601031819,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}