{"id":"W2103943686","doi":"10.1093/hmg/ddn353","title":"Epigenetics in multiple sclerosis susceptibility: difference in transgenerational risk localizes to the major histocompatibility complex","year":2008,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":97,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Wellcome Trust","keywords":"Biology; Genetics; Haplotype; Allele; Human leukocyte antigen; Linkage disequilibrium; Sibling; Epigenetics; Immunology; Gene; Antigen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005296083,0.0003140289,0.0005215508,0.0002354726,0.0003606149,0.00002566144,0.0003703963,0.0001108663,0.0001333577],"category_scores_gemma":[0.0004961108,0.000259214,0.0001532318,0.0005184404,0.0005465643,0.0000171607,0.0001929999,0.0004547654,0.00002545389],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000324619,"about_ca_system_score_gemma":0.0001381055,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001193858,"about_ca_topic_score_gemma":0.02461151,"domain_scores_codex":[0.9966414,0.000497154,0.0007272772,0.0007043136,0.0008377164,0.0005921668],"domain_scores_gemma":[0.9983066,0.0001873163,0.00008118376,0.0009629888,0.0002242475,0.0002376508],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001043189,0.000481014,0.6939098,0.00004553397,0.00003720566,0.00002744466,0.001578149,0.004398723,0.2965096,0.0000217908,0.000222391,0.002664104],"study_design_scores_gemma":[0.002344866,0.0003095217,0.975934,0.00005927913,0.00002609969,0.000003629544,0.00008490715,0.009372304,0.01109817,0.0001066715,0.0004175151,0.0002430247],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907761,0.0009600223,0.005179622,0.0006893378,0.00003849857,0.002158652,0.00007232955,0.00003102359,0.0000943965],"genre_scores_gemma":[0.9919828,0.0005088337,0.006633265,0.0004123667,0.00006811842,0.000249196,0.00005757022,0.00003970211,0.00004820234],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2854114,"threshold_uncertainty_score":0.999986,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1672652570948232,"score_gpt":0.3265302692507952,"score_spread":0.159265012155972,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}