{"id":"W2103951108","doi":"10.4049/jimmunol.1002747","title":"Forced Expression of HLA-DM at the Surface of Dendritic Cells Increases Loading of Synthetic Peptides on MHC Class II Molecules and Modulates T Cell Responses","year":2011,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Royal Victoria Hospital; McGill University Health Centre; Royal Victoria Regional Health Centre; Université de Montréal","funders":"","keywords":"CD8; Cytotoxic T cell; T cell; Epitope; Cell biology; Major histocompatibility complex; MHC class I; Dendritic cell; Biology; Cancer immunotherapy; Antigen-presenting cell; Antigen presentation; Molecular biology; Chemistry; Antigen; Immunotherapy; Immune system; Immunology; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001055044,0.0001841638,0.0001916079,0.00009887457,0.00008582763,0.0003236382,0.00008675746,0.0002058264,0.000688348],"category_scores_gemma":[0.0001332329,0.0001068861,0.0001169597,0.0001142766,0.0001690711,0.0001610189,0.0001674831,0.0004340707,0.0002859901],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002229393,"about_ca_system_score_gemma":0.0001263442,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001392543,"about_ca_topic_score_gemma":0.0002083379,"domain_scores_codex":[0.9998564,0.00002985069,0.00001592819,0.00002439765,0.00002644286,0.00004697019],"domain_scores_gemma":[0.9999015,0.00002399928,0.00002303346,0.00001489447,0.000007501463,0.00002899795],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005443272,0.00001486254,0.000148173,0.000007989566,0.000001325788,0.0000116778,0.00000382519,0.00003353685,0.99933,0.00002787449,0.000008923194,0.0003573404],"study_design_scores_gemma":[0.00001500038,0.0001848023,0.002096052,0.000002928508,0.000009051317,0.00008567143,0.00001996594,0.0007638211,0.9957681,0.00003009433,0.001022106,0.000002598345],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998679,0.0002586702,0.0005361837,0.00003157243,0.00001091837,0.000004848374,0.00006353815,0.00001126531,0.0004040129],"genre_scores_gemma":[0.9983486,0.0002741985,0.0006828482,0.00002781715,0.000006408141,0.000008054791,0.00009907171,0.000009824473,0.0005431206],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000688348,"threshold_uncertainty_score":0.002302766,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01378372519118761,"score_gpt":0.2197817808865462,"score_spread":0.2059980556953586,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}