{"id":"W2104026530","doi":"10.4049/jimmunol.1102503","title":"Regulation of VH Replacement by B Cell Receptor–Mediated Signaling in Human Immature B Cells","year":2013,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Allergy and Infectious Diseases","keywords":"Syk; breakpoint cluster region; Biology; CD19; B-cell receptor; Cell biology; B cell; Signal transduction; Gene; Antibody; Molecular biology; Tyrosine kinase; Immunology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009293645,0.0001495698,0.0001769652,0.0001431917,0.0001028997,0.0002782959,0.00008612457,0.0001362327,0.000971796],"category_scores_gemma":[0.0001128525,0.00007300288,0.0001133814,0.0001184491,0.0001086619,0.00008209599,0.0001102836,0.0002816439,0.0002644917],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001913869,"about_ca_system_score_gemma":0.0001258004,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004223309,"about_ca_topic_score_gemma":0.0003077798,"domain_scores_codex":[0.9998931,0.00002188953,0.000008922875,0.00001787908,0.00002774741,0.00003044906],"domain_scores_gemma":[0.9999472,0.00001413757,0.0000142814,0.000007128638,0.000006385404,0.00001075412],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001545523,0.00001513233,0.0002745713,0.00001377909,0.000001694607,0.00004833119,0.00001568058,0.00003186348,0.9972856,0.00004010788,0.00002266259,0.002096042],"study_design_scores_gemma":[0.00002377987,0.000326961,0.01089325,0.000004283295,0.00001189519,0.0004485202,0.00003438012,0.000410188,0.9859813,0.00005515272,0.001806542,0.000003706437],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997005,0.001188362,0.0009518196,0.00002357126,0.00000538294,0.00001181963,0.0001374762,0.00003984071,0.0006366769],"genre_scores_gemma":[0.9975883,0.0005977827,0.0008367021,0.0000224301,0.000005333929,0.00001574394,0.0003154693,0.000005931324,0.000612271],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000971796,"threshold_uncertainty_score":0.003250957,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00615729214236246,"score_gpt":0.2021081114823584,"score_spread":0.1959508193399959,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}