{"id":"W2104049989","doi":"10.1242/bio.011544","title":"Saponin-permeabilization is not a viable alternative to isolated mitochondria for assessing oxidative metabolism in hibernation","year":2015,"lang":"en","type":"article","venue":"Biology Open","topic":"Adipose Tissue and Metabolism","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"National Institutes of Health","keywords":"Torpor; Biology; Mitochondrion; Citrate synthase; Hibernation (computing); Saponin; Oxidative phosphorylation; Biochemistry; Succinate dehydrogenase; Respiration; Metabolism; Cellular respiration; Enzyme; Endocrinology; Anatomy; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002923075,0.0004826631,0.0004780306,0.0002925514,0.0003336014,0.0006875965,0.0003980149,0.0005038648,0.001852213],"category_scores_gemma":[0.0002389321,0.0002471815,0.0002699837,0.0002138064,0.0005920685,0.0009003544,0.000377443,0.0009149619,0.0006077752],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002684184,"about_ca_system_score_gemma":0.0002386903,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004172148,"about_ca_topic_score_gemma":0.001148155,"domain_scores_codex":[0.9997976,0.00002651626,0.00002256733,0.00007375686,0.00003760219,0.00004201482],"domain_scores_gemma":[0.9997126,0.00009032511,0.00008335356,0.0000431105,0.00003379741,0.00003673579],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006659515,0.000006139413,0.0002506138,0.00006944051,0.000007747464,0.00005327739,0.00002702989,0.00002065378,0.9986798,0.00006063979,0.00001881897,0.0007393345],"study_design_scores_gemma":[0.00001433332,0.0002664033,0.02055673,0.0000376584,0.00004582002,0.0007074912,0.0001402046,0.00077049,0.974126,0.000260009,0.003064003,0.00001090371],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9609659,0.007041436,0.02665408,0.0005246972,0.0001693513,0.00008689703,0.0008695444,0.0003089205,0.003379143],"genre_scores_gemma":[0.9772221,0.004064837,0.01413074,0.000240007,0.00004952315,0.0001137949,0.001385709,0.0001362792,0.00265703],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001852213,"threshold_uncertainty_score":0.00619626,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09442420585425804,"score_gpt":0.4066917209822427,"score_spread":0.3122675151279846,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}