{"id":"W2104049989","doi":"10.1242/bio.011544","title":"Saponin-permeabilization is not a viable alternative to isolated mitochondria for assessing oxidative metabolism in hibernation","year":2015,"lang":"en","type":"article","venue":"Biology Open","topic":"Adipose Tissue and Metabolism","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"National Institutes of Health","keywords":"Torpor; Biology; Mitochondrion; Citrate synthase; Hibernation (computing); Saponin; Oxidative phosphorylation; Biochemistry; Succinate dehydrogenase; Respiration; Metabolism; Cellular respiration; Enzyme; Endocrinology; Anatomy; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004854963,0.0001634935,0.0004754744,0.000209405,0.00005531231,0.0000517859,0.0002377093,0.0001568412,0.00007747416],"category_scores_gemma":[0.0006746491,0.0001391446,0.00004203094,0.0003164924,0.00004154116,0.0003792739,0.0001416364,0.0001129033,0.00007600433],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001023934,"about_ca_system_score_gemma":0.0002550071,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009239881,"about_ca_topic_score_gemma":0.00008809988,"domain_scores_codex":[0.9987387,0.000130755,0.0003211678,0.0004273365,0.0001026734,0.0002793424],"domain_scores_gemma":[0.9989772,0.00008559983,0.0001368871,0.0002296446,0.0004000816,0.0001705972],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00437207,0.0007214819,0.01326615,0.00005115678,0.0005275334,0.00002768937,0.01818056,0.0001374107,0.8776343,0.02614641,0.01748546,0.04144977],"study_design_scores_gemma":[0.02061656,0.001251966,0.038355,0.0002679046,0.0004539708,0.00004920162,0.001448912,0.008516218,0.2986608,0.01117046,0.6183735,0.0008355255],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9595079,0.0004353187,0.02617481,0.004840159,0.001058516,0.003916275,0.00006287492,0.00004394156,0.003960189],"genre_scores_gemma":[0.9641355,0.00002577979,0.0257409,0.004222869,0.000383275,0.0004161665,0.000285508,0.00003690151,0.004753134],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.600888,"threshold_uncertainty_score":0.5674154,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09442420585425804,"score_gpt":0.4066917209822427,"score_spread":0.3122675151279846,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}