{"id":"W2104065542","doi":"10.1016/s0140-6736(14)60920-x","title":"Efficacy, safety, and immunogenicity of the human papillomavirus 16/18 AS04-adjuvanted vaccine in women older than 25 years: 4-year interim follow-up of the phase 3, double-blind, randomised controlled VIVIANE study","year":2014,"lang":"en","type":"article","venue":"The Lancet","topic":"Cervical Cancer and HPV Research","field":"Medicine","cited_by":182,"is_retracted":false,"has_abstract":false,"ca_institutions":"Women's Health Research Institute; University of British Columbia; Quebec - Clinical Research Organization in Cancer; University of Alberta","funders":"Merck Sharp and Dohme; GlaxoSmithKline","keywords":"Medicine; Vaccine efficacy; Clinical endpoint; Cervical cancer; Interim analysis; Cohort; Population; Vaccination; HPV infection; Serostatus; Cervical intraepithelial neoplasia; Internal medicine; Randomized controlled trial; Immunology; Cancer; Viral load; Virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003551593,0.00135253,0.002794625,0.0003598329,0.0004006271,0.0008684712,0.0009909497,0.002370758,0.002517114],"category_scores_gemma":[0.003451283,0.0007489613,0.00207942,0.0004320415,0.0013531,0.001115843,0.0004720416,0.002080323,0.0004805995],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007052876,"about_ca_system_score_gemma":0.00110691,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001616423,"about_ca_topic_score_gemma":0.001227889,"domain_scores_codex":[0.9984835,0.0009233875,0.0000770241,0.000158078,0.0001244583,0.0002335767],"domain_scores_gemma":[0.9981695,0.0006200681,0.0004540629,0.0002519241,0.0001368662,0.000367501],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9795039,0.005298383,0.002159082,0.0001947994,0.0006699598,0.00002843334,0.00009960432,0.0002042384,0.002882368,0.00004142649,0.0002134957,0.008704205],"study_design_scores_gemma":[0.7155226,0.2617075,0.01944255,0.00003028132,0.001077503,0.00004440988,0.00006917919,0.0002707806,0.001047052,0.0001589248,0.0005985302,0.00003067253],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972671,0.001289959,0.0001280865,0.0001143141,0.00007337701,0.0004090081,0.0003315788,0.00001402075,0.0003724939],"genre_scores_gemma":[0.9960473,0.0007944471,0.0003364145,0.0002409378,0.0001571701,0.0007284509,0.0005667174,0.00001033808,0.001118168],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003551593,"threshold_uncertainty_score":0.01878279,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04935868668928727,"score_gpt":0.3668805136667475,"score_spread":0.3175218269774602,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}