{"id":"W2104065542","doi":"10.1016/s0140-6736(14)60920-x","title":"Efficacy, safety, and immunogenicity of the human papillomavirus 16/18 AS04-adjuvanted vaccine in women older than 25 years: 4-year interim follow-up of the phase 3, double-blind, randomised controlled VIVIANE study","year":2014,"lang":"en","type":"article","venue":"The Lancet","topic":"Cervical Cancer and HPV Research","field":"Medicine","cited_by":182,"is_retracted":false,"has_abstract":false,"ca_institutions":"Women's Health Research Institute; University of British Columbia; Quebec - Clinical Research Organization in Cancer; University of Alberta","funders":"Merck Sharp and Dohme; GlaxoSmithKline","keywords":"Medicine; Vaccine efficacy; Clinical endpoint; Cervical cancer; Interim analysis; Cohort; Population; Vaccination; HPV infection; Serostatus; Cervical intraepithelial neoplasia; Internal medicine; Randomized controlled trial; Immunology; Cancer; Viral load; Virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00241654,0.000192748,0.00135535,0.00007505735,0.00010645,0.00002230449,0.0006716417,0.00007454633,0.001074871],"category_scores_gemma":[0.0002952919,0.00008921634,0.0002185298,0.0003506193,0.000190147,0.00003355199,0.0003733493,0.0004793788,0.000004679172],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009116716,"about_ca_system_score_gemma":0.0000636867,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006674173,"about_ca_topic_score_gemma":0.0006946982,"domain_scores_codex":[0.9975843,0.0006297341,0.0006401807,0.0002505025,0.000509506,0.0003857409],"domain_scores_gemma":[0.9980534,0.0004107463,0.000238588,0.00109222,0.0001270575,0.00007798443],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9290658,0.00182185,0.02797329,0.0001649157,0.0008021962,0.000003811775,0.007038553,0.000003641594,0.02218741,0.0001413219,0.0004416277,0.01035561],"study_design_scores_gemma":[0.6191159,0.0006744332,0.3766081,0.00008565657,0.0001397596,0.00000249937,0.000582108,0.00004026268,0.002240562,0.00009879316,0.000334269,0.00007761028],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99171,0.0003507912,0.000006942043,0.0009809729,0.0001222894,0.003730741,0.00002159282,0.00001694261,0.003059742],"genre_scores_gemma":[0.998744,0.0001036383,0.000002148625,0.0002458563,0.0002157092,0.0001153491,0.000004914235,0.00002457579,0.0005438062],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3486348,"threshold_uncertainty_score":0.9998383,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04935868668928727,"score_gpt":0.3668805136667475,"score_spread":0.3175218269774602,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}