{"id":"W2104068929","doi":"10.1002/glia.1125","title":"Malignant glioma cells use MHC class II transactivator (CIITA) promoters III and IV to direct IFN‐γ‐inducible CIITA expression and can function as nonprofessional antigen presenting cells in endocytic processing and CD4<sup>+</sup> T‐cell activation","year":2001,"lang":"en","type":"article","venue":"Glia","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"National Institute of Neurological Disorders and Stroke; National Institutes of Health; Boehringer Ingelheim Fonds; Hellman Family Foundation; National Multiple Sclerosis Society","keywords":"CIITA; MHC class II; Biology; Antigen presentation; Antigen-presenting cell; Antigen processing; Cell biology; Cancer research; MHC class I; Major histocompatibility complex; Antigen; T cell; Molecular biology; Immunology; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003827038,0.0003732696,0.0004292882,0.0003801071,0.0007175085,0.0001089212,0.0001322304,0.0003551144,0.00009291614],"category_scores_gemma":[0.00004554586,0.0003270361,0.00005167608,0.0003317645,0.0001585687,0.0006643403,0.0001217853,0.0003898477,0.000009284315],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007395482,"about_ca_system_score_gemma":0.0001379908,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005155051,"about_ca_topic_score_gemma":0.00001848081,"domain_scores_codex":[0.9977064,0.0004129364,0.0004498277,0.0007161506,0.0001051534,0.000609564],"domain_scores_gemma":[0.9991747,0.0002281109,0.0001878564,0.000270277,0.00006851419,0.00007060983],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003031968,0.0002231753,0.002277116,0.00008943432,0.00005188026,0.00001972417,0.006788928,0.00003731956,0.9806454,0.00000280347,0.0001520488,0.006680243],"study_design_scores_gemma":[0.003401516,0.0004857317,0.009564237,0.0005704397,0.00003577543,0.00008008827,0.002149913,0.0001505324,0.9769317,0.00002057686,0.006204218,0.0004052616],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967498,0.001541434,0.0001393178,0.0001963635,0.0002422053,0.0008821662,0.00001851854,0.0000640322,0.0001661279],"genre_scores_gemma":[0.9959086,0.0003895097,0.0001261926,0.0001391386,0.0000322095,0.00006331506,0.00003369449,0.00004519917,0.003262174],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007287121,"threshold_uncertainty_score":0.9999182,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0138341302930385,"score_gpt":0.232839975233063,"score_spread":0.2190058449400245,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}