{"id":"W2104085655","doi":"10.1093/embo-reports/kve084","title":"A novel ER α‐mannosidase‐like protein accelerates ER‐associated degradation","year":2001,"lang":"en","type":"article","venue":"EMBO Reports","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":463,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Medical Research Council; Medical Research Council Canada","keywords":"Endoplasmic-reticulum-associated protein degradation; Endoplasmic reticulum; Calnexin; Cell biology; Unfolded protein response; Glycoprotein; Biology; Protein folding; Glycan; Protein degradation; Mannosidase; Chemistry; Biochemistry; Calreticulin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001396033,0.0001832786,0.0001522692,0.00003681158,0.0001052048,0.00005694692,0.00008315041,0.0001491213,0.0001351767],"category_scores_gemma":[0.0002152348,0.0001685795,0.0001076335,0.000117322,0.00004326271,0.000009088024,0.00006919353,0.00007625151,0.00001427968],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002114762,"about_ca_system_score_gemma":0.00009837025,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009787029,"about_ca_topic_score_gemma":0.00006814934,"domain_scores_codex":[0.9987127,0.00002947989,0.0003327866,0.0004403303,0.0001994606,0.0002852413],"domain_scores_gemma":[0.9990869,0.000005405918,0.0002279437,0.0004023387,0.0001368936,0.0001404737],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006873042,0.0004322282,0.04181253,0.00001900348,0.00009218328,0.0004736659,0.00002166735,0.00007588029,0.9470121,0.00006296086,0.008955658,0.0009734292],"study_design_scores_gemma":[0.001987147,0.0004021265,0.1050942,0.0001516883,0.0001297864,0.000970585,0.0001209236,0.000306732,0.8020729,0.0004598421,0.08716206,0.001141969],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915355,0.0003255082,0.0005997004,0.0001678302,0.0001707445,0.0003311288,0.00001559826,0.00003096141,0.006823021],"genre_scores_gemma":[0.9884706,0.00004108502,0.0002942276,0.0002250931,0.0001357798,0.0001018491,0.000575487,0.00002656731,0.0101293],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1449391,"threshold_uncertainty_score":0.6874474,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01328992859906114,"score_gpt":0.2490004315372172,"score_spread":0.2357105029381561,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}