{"id":"W2104106878","doi":"10.1101/gad.1917610","title":"Mitotic chromosome condensation mediated by the retinoblastoma protein is tumor-suppressive","year":2010,"lang":"en","type":"article","venue":"Genes & Development","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":129,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children’s Health Research Institute; Western University","funders":"Canadian Institutes of Health Research; Cure Brain Cancer Foundation; Natural Sciences and Engineering Research Council of Canada; Children's Health Research Institute","keywords":"Biology; Mitosis; Premature chromosome condensation; Loss of heterozygosity; Retinoblastoma; Retinoblastoma protein; Cell biology; Cell cycle; Cancer research; Genetics; Chromosome; Chromosome instability; Chromosome segregation; Mutant; Prophase; Cancer; Gene; Meiosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001295673,0.0002590994,0.0001846674,0.0002699235,0.0001434512,0.000317333,0.000142784,0.0002032577,0.0009973376],"category_scores_gemma":[0.0001309014,0.0001158852,0.000168753,0.000111276,0.0002903637,0.000134351,0.0002141539,0.0002225086,0.0004724226],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002120527,"about_ca_system_score_gemma":0.0001403836,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003867801,"about_ca_topic_score_gemma":0.0004370066,"domain_scores_codex":[0.9999182,0.00001529714,0.000004976675,0.0000192286,0.00002481771,0.0000173995],"domain_scores_gemma":[0.9998943,0.00001322565,0.00004794475,0.00001417686,0.000009253485,0.00002114952],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005831349,0.00000556102,0.0002713465,0.00001847822,0.000003414348,0.00006722027,0.000006464876,0.00002827641,0.9978933,0.0002395758,0.00002575925,0.00138228],"study_design_scores_gemma":[0.00001456716,0.0002018865,0.006021617,0.000006060571,0.00001365236,0.001105748,0.00001339862,0.0004436928,0.9874686,0.0001279738,0.004579059,0.000003774643],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9797018,0.009710212,0.006481611,0.0001592601,0.0000400121,0.00001947454,0.000154037,0.0002200573,0.003513628],"genre_scores_gemma":[0.9954223,0.001986702,0.0007929218,0.00001801482,0.000007769789,0.000005712792,0.0001533363,0.00001599789,0.001597309],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009973376,"threshold_uncertainty_score":0.00333643,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007561923440685564,"score_gpt":0.2216635722523875,"score_spread":0.2141016488117019,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}