{"id":"W2104124411","doi":"10.1124/dmd.106.013508","title":"Animal Models of Acute Moderate Hypoxia Are Associated with a Down-Regulation of CYP1A1, 1A2, 2B4, 2C5, and 2C16 and Up-Regulation of CYP3A6 and P-glycoprotein in Liver","year":2007,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":87,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"Vlaamse regering","keywords":"Hypoxia (environmental); In vivo; P-glycoprotein; Glycoprotein; Biology; Cytochrome P450; Messenger RNA; In vitro; Gene expression; Downregulation and upregulation; Gene isoform; Pharmacology; Internal medicine; Endocrinology; Chemistry; Molecular biology; Biochemistry; Gene; Metabolism; Oxygen; Multiple drug resistance; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001127805,0.0002707633,0.000681926,0.0003133712,0.0001120927,0.0000180621,0.00006290742,0.0002442469,0.00002119819],"category_scores_gemma":[0.00002209866,0.0002408518,0.00004882339,0.0002783834,0.0003564552,0.0003877713,0.00007523237,0.0002281006,1.904484e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001328196,"about_ca_system_score_gemma":0.00003113654,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001228443,"about_ca_topic_score_gemma":0.00007356172,"domain_scores_codex":[0.9982014,0.0003081531,0.0006171981,0.0003558042,0.0002341401,0.0002832508],"domain_scores_gemma":[0.9987745,0.0001752349,0.0005553213,0.0001146886,0.0002156893,0.0001646202],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.004732687,0.0004446752,0.01124503,0.0002759575,0.0004432074,0.000009701154,0.005012625,0.001629563,0.9479991,0.008699873,0.00002815898,0.01947946],"study_design_scores_gemma":[0.004941042,0.00008610253,0.6803129,0.0001042447,0.0009651291,0.00001716974,0.0001898688,0.0696864,0.2397927,0.003583851,0.00005273036,0.0002678982],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888834,0.009037956,0.0007968229,0.00008514032,0.00009156075,0.0005735189,0.0003360407,0.00001515261,0.0001803495],"genre_scores_gemma":[0.9966493,0.002631813,0.0004144324,0.00008317517,0.00004866974,0.00001732982,0.00008380031,0.00002172608,0.00004976667],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7082064,"threshold_uncertainty_score":0.9821653,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03312668926294158,"score_gpt":0.3217105239375007,"score_spread":0.2885838346745591,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}