{"id":"W2104124411","doi":"10.1124/dmd.106.013508","title":"Animal Models of Acute Moderate Hypoxia Are Associated with a Down-Regulation of CYP1A1, 1A2, 2B4, 2C5, and 2C16 and Up-Regulation of CYP3A6 and P-glycoprotein in Liver","year":2007,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":87,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"Vlaamse regering","keywords":"Hypoxia (environmental); In vivo; P-glycoprotein; Glycoprotein; Biology; Cytochrome P450; Messenger RNA; In vitro; Gene expression; Downregulation and upregulation; Gene isoform; Pharmacology; Internal medicine; Endocrinology; Chemistry; Molecular biology; Biochemistry; Gene; Metabolism; Oxygen; Multiple drug resistance; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001991444,0.0006618072,0.0006148547,0.0005856488,0.0004040345,0.0003627951,0.0002921584,0.0004011946,0.002285857],"category_scores_gemma":[0.0001661189,0.0001880312,0.000408428,0.0003585016,0.0006721325,0.0002438556,0.0003380059,0.0008793658,0.0002476039],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007271213,"about_ca_system_score_gemma":0.0003946881,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001783554,"about_ca_topic_score_gemma":0.004293566,"domain_scores_codex":[0.9997397,0.00004969923,0.00001820689,0.00004500016,0.00008336829,0.00006395623],"domain_scores_gemma":[0.9994938,0.00004236565,0.0002770962,0.00004782629,0.00003218235,0.0001066029],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00722118,0.001306697,0.008892694,0.0004802926,0.0002843293,0.001353543,0.0001533467,0.0006617995,0.9647508,0.001422782,0.001974752,0.01149785],"study_design_scores_gemma":[0.0005354664,0.01953728,0.1764626,0.0001421532,0.0004867742,0.006765003,0.0006163257,0.004113217,0.7734945,0.001893336,0.01585712,0.00009614926],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9820941,0.002346892,0.009831534,0.0007753755,0.0002584432,0.0002142815,0.001817221,0.0002382714,0.002423835],"genre_scores_gemma":[0.9867491,0.002732186,0.00288112,0.0003058177,0.0001043559,0.0004344564,0.002672395,0.0000356706,0.004084833],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002285857,"threshold_uncertainty_score":0.007646978,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03312668926294158,"score_gpt":0.3217105239375007,"score_spread":0.2885838346745591,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}